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The modern era of research in immunology is characterized by an unprecedented level of detail about structural characteristics of the immune system and the regulation of activities of its numerous components, which function together as a whole distributed-parameter system. Mathematical modeling provides an analytical tool to describe, analyze, and predict the dynamics of immune responses by applying...
For bistable time-delay dynamical systems modeling the dynamics of viral infections and the virusinduced immune response, an efficient approach is proposed for constructing optimal disturbances of steady states with a high viral load that transfer the system to a state with a low viral load. Functions approximating the behavior of drugs within the framework of well-known pharmacokinetic models are...
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