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Sommario La polidipsia primaria (PP) è un condizione clinica rilevante per la frequenza con cui si manifesta nei pazienti psichiatrici e per le conseguenze gravi e potenzialmente fatali legate allo sviluppo di iponatriemia. Sebbene l’80% dei pazienti con PP siano schizofrenici, essa può presentarsi in un ampio spettro di malattie psichiatriche e anche nei decadimenti cognitivi. La PP ha una prevalenza...
Background Acromegalic patients have a higher risk of developing colorectal tumours (CRT). The common C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene is a well-documented CRT risk factor in the general population, but its role in acromegaly has never been examined. Purpose We investigated the influence of MTHFR C677T polymorphism, folate status and other lifestyle, nutritional...
Riassunto Il 5% di tutti gli adenomi ipofisari ha una base eredo-familiare. Le forme più comuni sono la MEN1 e la FIPA, mentre più rare sono la Carney Complex e la MEN4. Nuovi geni, ad esempio AIP, sono risultati associati a queste forme genetiche. È necessario conoscere l’esistenza di forme familiari di adenomi ipofisari, il corretto iter diagnostico anche genetico, l’appropriato screening e follow-up...
Data on osteoporotic fractures in hyperprolactinemia are limited. An increased prevalence of radiological vertebral fractures was recently observed in women with prolactin (PRL)-secreting adenoma, whereas it is unknown whether this observation may reflect a more general increased risk of fractures in this disease and whether the prevalence of fractures in males is affected by gonadal status. Thirty-two...
Hyperprolactinemia may cause bone loss but data on fractures are scanty. The aim of this study was to evaluate the prevalence of vertebral fractures in women with prolactin (PRL)-secreting adenoma. In this cross-sectional study, 78 women (median age 45.5 years, range: 20–81) with PRL-secreting pituitary adenoma (66 with microadenoma and 12 with macroadenoma) and 156 control subjects, with normal PRL...
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