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Expanding antibiotics: A concise synthesis of dehydrohomoplatencin, a novel derivative of the naturally occurring antibiotic platencin, has been realized (see scheme). Notably, the synthesis of the ketolide portion of the molecule was achieved in only two exceedingly simple steps. Compared to platencin, dehydrohomoplatencin showed virtually equipotent antibacterial activity against Gram‐positive bacteria...
BACKGROUND:Intestinal bacteria have long been implicated in colorectal cancer pathology, and many reports point to a close linkage between Streptococcus bovis biotype I (recently renamed Streptococcus gallolyticus) infections and tumors of the human colon. This work aims to investigate the humoral immune response to this bacterium during different stages of colorectal cancer.
METHODS:The presence...
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