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Objectives
Despite of the aberrant expression of 14‐3‐3ζ in head and neck squamous cell carcinoma (HNSCC), little is known about the role of 14‐3‐3ζ in the regulation of senescence in HNSCC. This study was performed to investigate whether 14‐3‐3ζ is implicated in senescence evasion of Hep‐2 laryngeal cancer cells.
Methods
The expression of 14‐3‐3ζ was suppressed using RNA interference strategy...
BCL-2 interacting cell death suppressor (BIS), also known as BAG3, has been known to function as an anti-stress or anti-apoptotic protein. Due to high levels of BIS expression in most of cancer cell lines, strategies to suppress BIS and any subsequent increased sensitivity to apoptosis are usually employed in conjunction with the pro-survival activity of BIS. To overcome the limitations in verifying...
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