Search results for: Roberto Sciagrà

Items from 1 to 20 out of 76 results

article

Texture analysis of 18F‐FDG PET/CT and CECT: Prediction of refractoriness of Hodgkin lymphoma with mediastinal bulk involvement

Elisabetta M. Abenavoli, Flavia Linguanti, Matilde Anichini, Vittorio Miele, more

Hematological Oncology > 42 > 2 > n/a - n/a

To recognize patients at high risk of refractory disease, the identification of novel prognostic parameters improving stratification of newly diagnosed Hodgkin Lymphoma (HL) is still needed. This study investigates the potential value of metabolic and texture features, extracted from baseline 18F‐FDG Positron Emission Tomography/Computed Tomography (PET) and Contrast‐Enhanced Computed Tomography scan...

article

Coronary microvascular function is impaired in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Alessia Argirò, Roberto Sciagrà, Alberto Marchi, Matteo Beltrami, more

European Journal of Neurology > 28 > 11 > 3809 - 3813

Background and purpose Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare inherited disease caused by NOTCH3 gene mutations. Although the main clinical features reflect brain injury, CADASIL is a systemic microangiopathy, and cardiac involvement has been observed but not systematically assessed. We aimed to study the prevalence and severity...

article

EANM procedural guidelines for myocardial perfusion scintigraphy using cardiac-centered gamma cameras

Fabien Hyafil, Alessia Gimelli, Riemer H. J. A. Slart, Panagiotis Georgoulias, more

European Journal of Hybrid Imaging > 2019 > 3 > 1 > 1-27

An increasing number of Nuclear Medicine sites in Europe are using cardiac-centered gamma cameras for myocardial perfusion scintigraphy (MPS). Three cardiac-centered gamma cameras are currently the most frequently used in Europe: the D-SPECT (Spectrum Dynamics), the Alcyone (Discovery NM 530c and Discovery NM/CT 570c; General Electric Medical Systems), and the IQ-SPECT (Siemens Healthcare). The increased...

article

Novel 3D heart left ventricle muscle segmentation method for PET-gated protocol and its verification

Tomasz Kubik, Krzysztof Kałużyński, Cyrill Burger, Alessandro Passeri, more

Annals of Nuclear Medicine > 2019 > 33 > 8 > 629-638

Objective The aim of this study was to propose and verify a universal method of left ventricular myocardium segmentation, able to operate on heart gated PET data with different sizes, shapes and uptake distributions. The proposed method can be classified as active model method and is based on the BEAS (B-spline Explicit Active Surface) algorithm published by Barbosa et al. The method was implemented...

article

Microvascular Dysfunction in Hypertrophic Cardiomyopathy

Roberto Sciagrà

Current Cardiovascular Imaging Reports > 2019 > 12 > 1 > 1-9

Purpose of Review In hypertrophic cardiomyopathy (HCM), the presence of vessel abnormalities with microvascular dysfunction is a well-known feature. The aim of this review is to present the evidences that support this notion and to describe the physiopathologic and clinical consequences of microvascular dysfunction. Recent Findings After having demonstrated the presence and significance of microvascular...

article

Prediction of functional recovery after primary PCI using the estimate of myocardial salvage in gated SPECT early after acute myocardial infarction

Raffaella Calabretta, Angelo Castello, Flavia Linguanti, Francesca Tutino, more

European Journal of Nuclear Medicine and Molecular Imaging > 2018 > 45 > 4 > 530-537

Purpose Primary percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) aims to achieve myocardial salvage (MS). Because the reference method for measuring MS requires myocardial perfusion imaging (MPI) after tracer injection before PCI, alternative approaches have been proposed, but none has gained wide acceptance. Gated SPECT MPI can assess infarct size (IS), but can also show...

article

Right ventricular perfusion: Do we need additional evidence or just a simple methodology?

Roberto Sciagrà

Journal of Nuclear Cardiology > 2019 > 26 > 1 > 272-274

See related article, doi: 10.1007/s12350-017-0954-4

article

Comparison between the summed difference score and myocardial blood flow measured by ¹³N-ammonia

Raffaele Giubbini, Alessia Peli, Elisa Milan, Roberto Sciagrà, more

Journal of Nuclear Cardiology > 2018 > 25 > 5 > 1621-1628

Background Both the myocardial perfusion pattern and myocardial blood flow (MBF) are used to assess patients with suspected coronary artery disease (CAD). The aim of this study was to compare the perfusion pattern (using the summed difference score [SDS]) to MBF in a consecutive group of patients undergoing PET/CT with 13 N-ammonia (¹³NH₃). Methods 47 consecutive patients, aged 65 ± 12 years (42...

article

Myocardial blood flow and left ventricular functional reserve in hypertrophic cardiomyopathy: a ¹³NH₃ gated PET study

Roberto Sciagrà, Raffaella Calabretta, Fabrizio Cipollini, Alessandro Passeri, more

European Journal of Nuclear Medicine and Molecular Imaging > 2017 > 44 > 5 > 866-875

Introduction Ischemia in hypertrophic cardiomyopathy (HCM) is caused by coronary microvascular dysfunction (CMD), which is detected by measuring myocardial blood flow (MBF) with PET. Whether CMD may be associated with ischemic left ventricular (LV) dysfunction is unclear. We therefore assessed LV ejection fraction (EF) reserve in HCM patients undergoing dipyridamole (Dip) PET. Methods Resting and...

article

Performance of cardiac cadmium-zinc-telluride gamma camera imaging in coronary artery disease: a review from the cardiovascular committee of the European Association of Nuclear Medicine (EANM)

Denis Agostini, Pierre-Yves Marie, Simona Ben-Haim, François Rouzet, more

European Journal of Nuclear Medicine and Molecular Imaging > 2016 > 43 > 13 > 2423-2432

The trade-off between resolution and count sensitivity dominates the performance of standard gamma cameras and dictates the need for relatively high doses of radioactivity of the used radiopharmaceuticals in order to limit image acquisition duration. The introduction of cadmium-zinc-telluride (CZT)-based cameras may overcome some of the limitations against conventional gamma cameras. CZT cameras used...

article

Role of quantitative myocardial positron emission tomography for risk stratification in patients with hypertrophic cardiomyopathy: a 2016 reappraisal

Helga Castagnoli, Cecilia Ferrantini, Raffaele Coppini, Alessandro Passeri, more

European Journal of Nuclear Medicine and Molecular Imaging > 2016 > 43 > 13 > 2413-2422

Aims Myocardial blood flow <1.1 mL/min/g following dipyridamole (Dip-MBF) assessed by positron emission tomography (PET) was identified in 2003 as an important outcome predictor in hypertrophic cardiomyopathy (HCM), based on scans performed in the 90s. However, such extreme Dip-MBF impairment is rarely observed in contemporary cohorts. We, therefore, reassessed the Dip-MBF threshold defining high-risk...

article

COmparison between COronary THrombus aspiration with Angiojet® or Export® catheter in patients with ST-elevation myocardial infarction submitted to primary angioplasty: The COCOTH Study

Cristina Giglioli, Emanuele Cecchi, Roberto Sciagrá, Giorgio Jacopo Baldereschi, more

International Journal of Cardiology > 2016 > 203 > Complete > 757-762

To compare the effects of two thrombus aspiration devices, the manual catheter Export® and the more complex and expensive mechanical Angiojet®, on several indices of reperfusion in acute ST-elevation myocardial infarction (STEMI).Clinical, hemodynamic and procedural characteristics of 185 STEMI patients, randomized to treatment with Export (n=95) or Angiojet (n=90) during primary percutaneous coronary...

article

Interventricular septum metastasis in neuroendocrine tumour

Angelo Castello, Vittorio Briganti, Roberto Sciagrà

Endocrine > 2016 > 53 > 3 > 870-871

article

Position paper of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM) on PET imaging of atherosclerosis

Jan Bucerius, Fabien Hyafil, Hein J. Verberne, Riemer H. J. A. Slart, more

European Journal of Nuclear Medicine and Molecular Imaging > 2016 > 43 > 4 > 780-792

Cardiovascular diseases are the leading cause of death not only in Europe but also in the rest of the World. Preventive measures, however, often fail and cardiovascular disease may manifest as an acute coronary syndrome, stroke or even sudden death after years of silent progression. Thus, there is a considerable need for innovative diagnostic and therapeutic approaches to improve the quality of care...

article

Segmental quantitative myocardial perfusion with PET for the detection of significant coronary artery disease in patients with stable angina

Valentina Berti, Roberto Sciagrà, Danilo Neglia, Mikko Pietilä, more

European Journal of Nuclear Medicine and Molecular Imaging > 2016 > 43 > 8 > 1522-1529

Purpose The goal of this study is to determine the technical accuracy of segmental perfusion parameters assessed with quantitative cardiac PET imaging in the evaluation of coronary artery disease (CAD) in patients with stable angina. Methods A cohort of patients who participated in the EVINCI protocol underwent an evaluation of coronary anatomy by invasive coronary angiography (ICA) and/or coronary...

article

Clinical use of quantitative cardiac perfusion PET: rationale, modalities and possible indications. Position paper of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM)

Roberto Sciagrà, Alessandro Passeri, Jan Bucerius, Hein J. Verberne, more

European Journal of Nuclear Medicine and Molecular Imaging > 2016 > 43 > 8 > 1530-1545

Until recently, PET was regarded as a luxurious way of performing myocardial perfusion scintigraphy, with excellent image quality and diagnostic capabilities that hardly justified the additional cost and procedural effort. Quantitative perfusion PET was considered a major improvement over standard qualitative imaging, because it allows the measurement of parameters not otherwise available, but for...

article

Matrix metalloproteinases and their tissue inhibitor after reperfused ST-elevation myocardial infarction treated with doxycycline. Insights from the TIPTOP trial

Giampaolo Cerisano, Piergiovanni Buonamici, Anna Maria Gori, Renato Valenti, more

International Journal of Cardiology > 2015 > 197 > Complete > 147-153

The TIPTOP (Early Short-term Doxycycline Therapy In Patients with Acute Myocardial Infarction and Left Ventricular Dysfunction to Prevent The Ominous Progression to Adverse Remodelling) trial demonstrated that a timely, short-term therapy with doxycycline is able to reduce LV dilation, and both infarct size and severity in patients treated with primary percutaneous intervention (pPCI) for a first...

article

Validation of pixel-wise parametric mapping of myocardial blood flow with ¹³ NH ₃ PET in patients with hypertrophic cardiomyopathy

Roberto Sciagrà, Alessandro Passeri, Fabrizio Cipollini, Helga Castagnoli, more

European Journal of Nuclear Medicine and Molecular Imaging > 2015 > 42 > 10 > 1581-1588

Purpose Transmural abnormalities in myocardial blood flow (MBF) are important causes of ischaemia in patients with left ventricular (LV) hypertrophy. The study aimed to test whether pixel-wise parametric mapping of ¹³ NH ₃ MBF can reveal transmural abnormalities in patients with hypertrophic cardiomyopathy (HCM). Methods We submitted 11 HCM patients...

article

The RUBY-10 Study

Sergey V. Nesterov, Emmanuel Deshayes, Roberto Sciagrà, Leonardo Settimo, more

JACC: Cardiovascular Imaging > 2014 > 7 > 11 > 1119-1127

The purpose of this study was to compare myocardial blood flow (MBF) and myocardial flow reserve (MFR) estimates from rubidium-82 positron emission tomography (⁸²Rb PET) data using 10 software packages (SPs) based on 8 tracer kinetic models.It is unknown how MBF and MFR values from existing SPs agree for ⁸²Rb PET.Rest and stress ⁸²Rb PET scans of 48 patients with suspected or known coronary artery...

article

Impact of multivessel disease on infarct size among STEMI patients undergoing primary angioplasty

Giuseppe De Luca, Guido Parodi, Roberto Sciagrà, Benedetta Bellandi, more

Atherosclerosis > 2014 > 234 > 1 > 244-248

Although primary angioplasty achieves Thrombolysis In Myocardial Infarction (TIMI) 3 flow in most patients with ST-elevation myocardial infarction, epicardial recanalization does not guarantee optimal perfusion in a large proportion of patients. Multivessel disease has been demonstrated to be associated with impaired survival, however its impact on infarct size has not been largely investigated, that...

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INFONA - science communication portal

Search results for: Roberto Sciagrà

Texture analysis of 18F‐FDG PET/CT and CECT: Prediction of refractoriness of Hodgkin lymphoma with mediastinal bulk involvement

Coronary microvascular function is impaired in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

EANM procedural guidelines for myocardial perfusion scintigraphy using cardiac-centered gamma cameras

Novel 3D heart left ventricle muscle segmentation method for PET-gated protocol and its verification

Microvascular Dysfunction in Hypertrophic Cardiomyopathy

Prediction of functional recovery after primary PCI using the estimate of myocardial salvage in gated SPECT early after acute myocardial infarction

Right ventricular perfusion: Do we need additional evidence or just a simple methodology?

Comparison between the summed difference score and myocardial blood flow measured by ¹³N-ammonia

Myocardial blood flow and left ventricular functional reserve in hypertrophic cardiomyopathy: a ¹³NH₃ gated PET study

Performance of cardiac cadmium-zinc-telluride gamma camera imaging in coronary artery disease: a review from the cardiovascular committee of the European Association of Nuclear Medicine (EANM)

Role of quantitative myocardial positron emission tomography for risk stratification in patients with hypertrophic cardiomyopathy: a 2016 reappraisal

COmparison between COronary THrombus aspiration with Angiojet® or Export® catheter in patients with ST-elevation myocardial infarction submitted to primary angioplasty: The COCOTH Study

Interventricular septum metastasis in neuroendocrine tumour

Position paper of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM) on PET imaging of atherosclerosis

Segmental quantitative myocardial perfusion with PET for the detection of significant coronary artery disease in patients with stable angina

Clinical use of quantitative cardiac perfusion PET: rationale, modalities and possible indications. Position paper of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM)

Matrix metalloproteinases and their tissue inhibitor after reperfused ST-elevation myocardial infarction treated with doxycycline. Insights from the TIPTOP trial

Validation of pixel-wise parametric mapping of myocardial blood flow with ¹³ NH ₃ PET in patients with hypertrophic cardiomyopathy

The RUBY-10 Study

Impact of multivessel disease on infarct size among STEMI patients undergoing primary angioplasty

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