Search results for: Yuko Okada

Items from 1 to 19 out of 19 results

article

Hemorrhagic duodenal ulcer as a rare complication prior to antiplatelet therapy for Kawasaki disease

Yusuke Hashimoto, Hideki Kumagai, Yuko Okada, Mitsuru Seki, more

Pediatrics International > 65 > 1 > n/a - n/a

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Predictive factors for postpartum glucose intolerance in women with gestational diabetes mellitus

Naohisa Masuko, Kenji Tanimura, Nobue Kojima, Hitomi Imafuku, more

Journal of Obstetrics and Gynaecology Research > 48 > 3 > 640 - 646

Aim The aim of this prospective cohort study was to evaluate the risk factors for postpartum glucose intolerance (GI) in women with gestational diabetes mellitus (GDM). Method A total of 140 women with GDM were enrolled. Of these, 115 underwent a 75‐g oral glucose tolerance test (OGTT) at 12 weeks after delivery. Clinical factors and parameters in the antepartum 75‐g OGTT associated with postpartum...

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Effects of insulin degludec and insulin glargine U300 on glycaemic stability in individuals with type 1 diabetes: A multicentre, randomized controlled crossover study

Hiroshi Miura, Kazuhiko Sakaguchi, Natsu Otowa‐Suematsu, Tomoko Yamada, more

Diabetes, Obesity and Metabolism > 22 > 12 > 2356 - 2363

To compare the effects of insulin degludec (IDeg) and insulin glargine U300 (IGlarU300) on glycaemic stability in subjects with type 1 diabetes. Materials and methods In this multicentre, crossover trial, 46 individuals with type 1 diabetes and essentially undetectable circulating C‐peptide were randomly assigned to either the IDeg‐first/IGlarU300‐second group or the IGlarU300‐first/IDeg‐second...

article

Cover Image, Volume 22, Issue 12

Hiroshi Miura, Kazuhiko Sakaguchi, Natsu Otowa‐Suematsu, Tomoko Yamada, more

Diabetes, Obesity and Metabolism > 22 > 12 > n/a - n/a

The cover image is based on the Original Article Effects of Insulin Degludec and Insulin Glargine U300 on Glycemic Stability in Individuals with Type 1 Diabetes: a Multicenter, Randomized Controlled Crossover Study by Hiroshi Miura et al., https://doi.org/10.1111/dom.14161.

article

A boy with duodenocolic fistula mimicking functional gastrointestinal disorder

Yuko Okada, Koji Yokoyama, Tomonori Yano, Hideki Kumagai, more

Clinical Journal of Gastroenterology > 2019 > 12 > 6 > 566-570

Duodenocolic fistula (DCF) is a rare disorder defined by the presence of an internal fistula between the duodenum and colon. Colon cancer, Crohn’s disease, diverticulum and duodenal ulcer are common causes of DCF, and vomiting and diarrhea are its main symptoms. We report a 14-year-old boy with DCF who had been treated for a functional gastrointestinal disorder (FGID). The boy had often experienced...

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Effects of exenatide and liraglutide on postchallenge glucose disposal in individuals with normal glucose tolerance

Yushi Hirota, Tomokazu Matsuda, Shinsuke Nakajima, Michinori Takabe, more

Endocrine > 2019 > 64 > 1 > 43-47

Purpose Glucagon-like peptide–1 receptor agonists (GLP-1RAs) are categorized as short- or long-acting types, but information regarding differences in the effects of these two types on postprandial glucose disposal has been limited. We have now investigated the effects of exenatide and liraglutide (short- and long-acting GLP-1RAs, respectively) on glucose disposal during an oral glucose tolerance test...

article

Experimental and Numerical Study on the Interface Behaviour Between the Rock Bolt and Bond Material

Yasuhiro Yokota, Zhiye Zhao, Wen Nie, Kensuke Date, more

Rock Mechanics and Rock Engineering > 2019 > 52 > 3 > 869-879

Conventional tunnelling methods (i.e., the drill and blast tunnelling method or the new Austrian tunnelling method) have been frequently applied for the construction of tunnels/caverns under a high overburden and with a large cross section. Under such adverse conditions, tunnel support materials may yield because of ground pressure and tunnel deformation. As a result, a tunnel may lose its stability...

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Effects of Insulin Degludec and Insulin Glargine U300 on Day-to-Day Fasting Plasma Glucose Variability in Individuals with Type 1 Diabetes: A Multicenter, Randomized, Crossover Study (Kobe Best Basal Insulin Study 2)

Hiroshi Miura, Kazuhiko Sakaguchi, Yuko Okada, Natsu Otowa-Suematsu, more

Diabetes Therapy > 2018 > 9 > 6 > 2399-2406

Introduction Administered basal insulin markedly influences the fasting plasma glucose (FPG) level of individuals with type 1 diabetes. Insulin degludec (IDeg) and insulin glargine U300 (IGlar U300) are now available as ultra-long-acting insulin formulations, but whether or how their glucose-stabilizing effects differ remains unclear. We will compare the effects of these basal insulins on parameters...

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Comprehensive Evaluation of Combination Therapy with Basal Insulin and Either Lixisenatide or Vildagliptin in Japanese Patients with Type 2 Diabetes: A Randomized, Open-Label, Parallel-Group, Multicenter Study

Natsu Otowa-Suematsu, Kazuhiko Sakaguchi, Tomoaki Nakamura, Kenta Hara, more

Diabetes Therapy > 2018 > 9 > 5 > 2067-2079

Introduction We comprehensively evaluated the effects of combination therapy with insulin glargine and the incretin-based drugs lixisenatide or vildagliptin in Japanese patients with type 2 diabetes. Methods In this 12-week, randomized, open-label, parallel-group, multicenter study (GLP-ONE Kobe), the incretin-based drug sitagliptin was randomly switched to lixisenatide (20 μg/day, n = 18) or vildagliptin...

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Effect of switching from conventional continuous subcutaneous insulin infusion to sensor augmented pump therapy on glycemic profile in Japanese patients with type 1 diabetes

Atsuko Matsuoka, Yushi Hirota, Shin Urai, Tetsushi Hamaguchi, more

Diabetology International > 2018 > 9 > 3 > 201-207

Aims Evidence suggests that sensor augmented pump (SAP) therapy is superior to conventional continuous subcutaneous insulin infusion (CSII) for achieving glycemic control in patients with type 1 diabetes. However, the clinical benefit of SAP therapy in East Asians has not yet been demonstrated. Methods The effect of switching from conventional CSII to SAP therapy on glycemic profile was examined...

article

Sex Differences in the Blood Concentration of Tacrolimus in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients with *CYP3A5**3/*3

Ayano Ito, Yuko Okada, Tadahiro Hashita, Tohru Aomori, more

Biochemical Genetics > 2017 > 55 > 3 > 268-277

The purpose of this study was to describe the impact of sex and cytochrome P450 3A5 (CYP3A5) variant on the blood concentration of tacrolimus in patients with systemic lupus erythematosus or rheumatoid arthritis. The blood concentration of tacrolimus (ng/mL) divided by the daily dose of tacrolimus (mg/day) and the patient’s weight (kg) (C/D) was obtained from 55 patients. The C/D value was analysed...

article

Hematoma of the ligamentum flavum in the thoracic spine: report of two cases and possible role of the transforming growth factor beta-vascular endothelial growth factor signaling axis in its pathogenesis

Yoshihiro Matsumoto, Toshifumi Fujiwara, Ryuta Imamura, Yuko Okada, more

Journal of Orthopaedic Science > 2013 > 18 > 2 > 347-354

article

Adding coronary artery bypass grafting to aortic valve replacement increases operative mortality for elderly (70 years and older) patients with aortic stenosis

Yasuyuki Sasaki, Hidekazu Hirai, Mitsuharu Hosono, Yasuyuki Bito, more

General Thoracic and Cardiovascular Surgery > 2013 > 61 > 11 > 626-631

Objective This retrospective study aimed to determine the effect of simultaneous aortic valve replacement (AVR) and coronary artery bypass grafting (CABG) on operative outcomes and long-term survival in elderly patients with a high prevalence of comorbidity. Methods One hundred and fifty-seven elderly patients (70 years old or older) undergoing isolated AVR (n = 120) or combined AVR/CABG (n = 37)...

article

Macrophage Infiltration Predicts a Poor Prognosis for Human Ewing Sarcoma

Toshifumi Fujiwara, Jun-ichi Fukushi, Shunsaku Yamamoto, Yoshihiro Matsumoto, more

The American Journal of Pathology > 2011 > 179 > 3 > 1157-1170

Ewing sarcoma–primitive neuroectodermal tumor (EWS) is associated with the most unfavorable prognosis of all primary musculoskeletal tumors. The objective of the present study was to investigate whether tumor-associated macrophages (TAMs) affect the development of EWS. TAMs were isolated from mouse xenografts using CD11b magnetic beads and examined for their cytokine expression and osteoclastic differentiation...

article

Thermosensitive properties of semi-IPN gel composed of amphiphilic gel and zwitterionic thermosensitive polymer in buffer solutions containing high concentration salt

Atsushi Takahashi, Kenta Hamai, Yuko Okada, Shuji Sakohara

Polymer > 2011 > 52 > 17 > 3791-3799

In this study, a semi-interpenetrating polymer network (semi-IPN) gel, which consists of an amphiphilic N,N-dimethylacrylamide-co-N-isopropylacrylamide (DMAA-co-NIPAM) gel and an interpenetrating zwitterionic thermosensitive poly(N-isopropylacrylamide-co-N,N-dimethyl(acrylamidopropyl)ammonium propane sulfonate) (poly(NIPAM-co-DMAAPS)) was prepared. The thermosensitive behavior of the semi-IPN gel...

article

Genetic polymorphism of CYP2C9 and CYP2C19 in a Bolivian population: an investigative and comparative study

Heydy V. Bravo-Villalta, Koujirou Yamamoto, Katsunori Nakamura, Ana Bayá, more

European Journal of Clinical Pharmacology > 2005 > 61 > 3 > 179-184

ObjectiveSeveral reports of CYP2C genetic polymorphism demonstrate its potential clinical role in determining both inter-individual and inter-ethnic differences in drug efficacy. We estimated the distribution of CYP2C9 and CYP2C19 common variants in the Bolivian population (a South American population), and compared these data with those from Asian, African, Caucasian and Oceanian populations.MethodsGenomic...

article

Effect of the single CYP2C9*3 allele on pharmacokinetics and pharmacodynamics of losartan in healthy Japanese subjects

Kazuishi Sekino, Takahiro Kubota, Yuko Okada, Yasuhiko Yamada, more

European Journal of Clinical Pharmacology > 2004 > 59 > 8-9 > 589-592

Objective. Losartan is metabolized to the active carboxylic acid metabolite EXP3174 by CYP2C9. In this study, we determined the effects of the single CYP2C9*3 variant on the pharmacokinetics and pharmacodynamics of losartan. Methods. Seven healthy Japanese subjects (CYP2C9*1/*1, n=4 and CYP2C9*1/*3, n=3) were phenotyped with a single dose of losartan (25mg). Blood and urine samples were collected...

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Electronic structures of cumulene type carbyne model compounds: a typical example of one-dimensional quantum well

Shojun Hino, Yuko Okada, Kentaro Iwasaki, Masashi Kijima, more

Chemical Physics Letters > 2003 > 372 > 1-2 > 59-65

Ultraviolet photoelectron spectra of linear chain cumulene type carbyne model compounds with phenyl terminal groups to stabilize the chain have been measured and assigned with semi-empirical molecular orbital (MO) calculation. The spectra can be basically divided into two parts; contributions from phenyl groups and the chain part. The longer the chain length becomes, the lower the binding energy of...

article

A comparative study of the treatment of chronic subdural hematoma-burr hole drainage versus burr hole irrigation

Yuko Okada, Takuya Akai, Kazuya Okamoto, Takaaki Iida, more

Surgical Neurology > 2002 > 57 > 6 > 405-409

BACKGROUNDSeveral surgical procedures have been reported for the treatment of chronic subdural hematoma. Whether irrigation is required is not clear. We compared the results of treatment of chronic subdural hematoma obtained with burr hole drainage and burr hole irrigation retrospectively.METHODSForty patients with chronic subdural hematoma underwent surgery at our institution in the last 3 years...

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