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High throughput whole transcriptome sequencing led to the discovery of a new class of non-coding RNAs: circular RNAs (circRNAs). Such single-stranded continuous loop RNAs exist for thousands of genes. Here, we present an overview of circRNA discovery and formation. We sum up some circRNA detection methods and highlight different molecular mechanisms of action. However, circRNA functional characterization...
In Philadelphia-positive chronic myeloid leukemia (CML), imatinib resistance frequently emerges because of point mutations in the ABL1 kinase domain, but may also be the consequence of uncontrolled upstream signaling. Recently, the heteromeric transcription factor GA-binding protein (GABP) was found to promote CML-like myeloproliferative disease in mice. In a cohort of 70 CML patients, we found that...
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