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NRF2 is a master regulator of the cellular protection against oxidative damage in mammals and of multiple pathways relevant in the mammalian aging process. In the epidermis of the skin NRF2 contributes additionally to the formation of an antioxidant barrier to protect from environmental insults and is involved in the differentiation process of keratinocytes. In chronological aging of skin, the capacity...
Starting from commercially available DMSAuCl and diazonium salts, cationic [
]AuIII complexes were synthesized in a selective, photosensitizer‐free, photochemical reaction by irradiation with blue LED light. This new protocol represents the first easy synthesis of these types of pincer complexes in moderate to excellent yield starting from a readily available gold(I) precursor with nitrogen as...
With around 351. 8 billion Euro the cohesion policy accounts for almost one third of the European Union’s budget in the period 2014–2020. Numerous programmes and projects are co-funded by the so-called European Structural and Investment Funds (ESIF). Errors in public procurement cause almost half of all irregularities detected in these programmes and projects. Many of these errors could be avoided...
In the last decade many approaches have been introduced that allow for automatic classification of brain tumors by means of pattern recognition and magnetic resonance spectroscopy. Despite promising classification accuracies, none of these methods has found its way into clinical practice, which is also related to the missing transparency for the basis of their decision making. In this work, we develop...
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