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Background In recent years, an adaptive endoplasmic reticulum (ER) stress response has been actively investigated. The ER membrane, isolated from the intact and regenerating liver, may be an appropriate model for investigating the association between structural and functional characteristics of ER in vivo and their corresponding behavioral characteristics in vitro. The rate of lipid synthesis and...
Apoptosis in tissues is induced by different kind of signals including endogenous aldehydes, such as 4-hydroxy-2, 3-nonenal. The accumulation rate of aldehydes in the cell is affected by conditions of oxidative stress. In the cell, aldehydes can be metabolized by various isoforms of aldehyde dehydrogenase, aldehyde reductase, and glutathione-S-transferase. There is evidence suggesting that the catalytic...
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