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Cetuximab therapy, which heavily relies on the activation of Ras pathway, has been used in KRAS, NRAS, BRAF, and PIK3CA wild‐type colorectal cancer (CRC) (Ras‐normal). However, the response rate only reached 60%, due to false‐negative mutation detection and mutation‐like transcriptome features in wild‐type patients. Herein, by integrating RNA‐seq, microarray, and mutation data, we developed a Ras...
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