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In this paper, we report a series of quinoline-pyrimidine linked calix[4]arene derivatives functionalized with 8-amino quinoline, 5-amino quinoline, 8-hydroxy quinoline, 2-amino pyrimidine and 4-amino 3-methyl quinoline. The synthesized compounds were purified and characterized by elemental analysis, FT-IR, 1H NMR and ESI-MS and screened for their anti-malarial activity against plasmodium falciparum...