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Microphthalmia-associated transcription factor (MITF) is a member of MYC superfamily, associated with melanocyte cells, as it was discovered in depigmented mice. However, over the last years it was found to be involved in many cellular signaling pathways, among which oncogenesis, osteoclast differentiation, and stress response. In mammals, Mitf gene mutations can cause diverse syndromes affecting...
Growing evidence suggests that the transcription factors belonging to the Jun family are involved in many important cellular events, such as the control of bone development in mammalians. We have characterized, for the first time, a member of the Jun family from embryos of the sea urchin Paracentrotus lividus. The Pl‐jun protein sequence includes all the functional domains characteristic of members...
The increase of UVB radiation reaching marine environment has harmful effects on living organisms. Paracentrotus lividus sea urchin embryos living in shallow water are exposed to radiations, providing a good model for studying the molecular mechanisms activated upon UV stress. Here, we report the modulated time- and dose-dependent expression of six genes, known to be involved in stress response, in...
Metallothioneins (MTs) constitute a family of cysteine-rich, low molecular weight proteins, which generally provide protection against metal toxicity and oxidative stress counteracting the cell damage caused by essential and non-essential heavy metals. Equally important is the physiological role of MTs in the homeostasis of essential metals, which are involved in a wide variety of cellular processes...
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