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Sensitive methods for the determination of three potentially genotoxic impurities (PGIs), namely 1-bromo-3-chloropropane (BCP), 1-(4-nitrobenzyl)-1H-1,2,4-triazole (NBT), and 1-(bromomethyl)-4-nitrobenzene (BNB) in rizatriptan benzoate (RTB) have been developed using hyphenated techniques. BCP was determined by GC–MS, while NBT and BNB were determined by LC–MS. These techniques have been selected...