Search results for: Shigeru Murakami

Items from 1 to 20 out of 45 results

article

Taurine attenuates the development of hepatic steatosis through the inhibition of oxidative stress in a model of nonalcoholic fatty liver disease in vivo and in vitro

Shigeru Murakami, Ayuko Ono, Azusa Kawasaki, Takaaki Takenaga, more

Amino Acids > 2018 > 50 > 9 > 1279-1288

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. It is characterized by the accumulation of triglyceride within hepatocytes. Taurine is a sulfur-containing-β-amino acid that is widely distributed in mammalian tissues. The objective of this study was to examine the effects of taurine on the development of hepatic steatosis in a model of NAFLD in vivo and in...

article

Mass spectrometry-based metabolomics to identify taurine-modified metabolites in heart

Takashi Ito, Koei Okazaki, Daisuke Nakajima, Daisuke Shibata, more

Amino Acids > 2018 > 50 > 1 > 117-124

Taurine is an abundant beta-amino acid found in high concentration in mammalian tissues. Taurine possesses many beneficial functions in mammalian cells. There are also a variety of taurine-conjugated products formed between taurine and bile acids, fatty acids, chloramine, mitochondrial tRNA, etc., and some of these have been identified as functional compounds. In the present study, we identified taurine-conjugated...

article

The physiological and pathophysiological roles of taurine in adipose tissue in relation to obesity

Shigeru Murakami

Life Sciences > 2017 > 186 > C > 80-86

Obesity is caused by an imbalance between energy intake and energy expenditure. It is established that obesity is a state of low-grade chronic inflammation, which is characterized by enlarged hypertrophied adipocytes, increased infiltration by macrophages and marked changes in the secretion of adipokines and free fatty acids. The effects of taurine on the pathogenesis of obesity have been reported...

article

Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARγ Activation

Mari Iwase, Takayuki Yamamoto, Kanako Nishimura, Haruya Takahashi, more

Lipids > 2017 > 52 > 7 > 657-664

Although the Apiaceae herb family has been traditionally used for the management of type 2 diabetes, its molecular mechanism has not been clarified. Coumarin derivatives, which are abundant in plants of the Apiaceae family, were evaluated for their effects on adipogenesis. We found that suksdorfin significantly promoted adipocyte differentiation and enhanced production of adiponectin, an anti-diabetic...

article

Xanthoangelol and 4‐hydroxyderrcin suppress obesity‐induced inflammatory responses

Yongjia Li, Tsuyoshi Goto, Ryuma Ikutani, Shan Lin, more

Obesity > 24 > 11 > 2351 - 2360

Objective Obesity‐induced inflammation plays a pivotal role in the pathogenesis of insulin resistance and type 2 diabetes. Xanthoangelol (XA) and 4‐hydroxyderrcin (4‐HD), phytochemicals extracted from Angelica keiskei, have been reported to possess various biological properties. Whether XA and 4‐HD alleviate obesity‐induced inflammation and inflammation‐induced adipocyte dysfunction was investigated...

article

Taurine ameliorates cholesterol metabolism by stimulating bile acid production in high‐cholesterol‐fed rats

Shigeru Murakami, Michiko Fujita, Masakazu Nakamura, Masanobu Sakono, more

Clinical and Experimental Pharmacology and Physiology > 43 > 3 > 372 - 378

This study was designed to investigate the effects of dietary taurine on cholesterol metabolism in high‐cholesterol‐fed rats. Male Sprague‐Dawley rats were randomly divided into two dietary groups (n = 6 in each group): a high‐cholesterol diet containing 0.5% cholesterol and 0.15% sodium cholate, and a high‐cholesterol diet with 5% (w/w) taurine. The experimental diets were given for 2 weeks. Taurine...

chapter

Taurine as the Nutritional Factor for the Longevity of the Japanese Revealed by a World-Wide Epidemiological Survey

Yukio Yamori, Longjian Liu, Mari Mori, Miki Sagara, more

Advances in Experimental Medicine and Biology > Taurine 7 > Cardiovascular and Renal Effects of Taurine > 13-25

The initial observation that taurine (T) prevented stroke in stroke-prone spontaneously hypertensive rats (SHRSP) led us to study the effects of T on cardiovascular diseases (CVD), as well as the epidemiological association of T and mortality rates, by using the data from WHO-coordinated Cardiovascular Disease and Alimentary Comparison Study, which covered 61 populations in 25 countries. In this study,...

article

4-Hydroxyderricin, as a PPARγ Agonist, Promotes Adipogenesis, Adiponectin Secretion, and Glucose Uptake in 3T3-L1 Cells

Yongjia Li, Tsuyoshi Goto, Kanae Yamakuni, Haruya Takahashi, more

Lipids > 2016 > 51 > 7 > 787-795

Adipocyte differentiation plays a pivotal role in maintaining the production of small-size adipocytes with insulin sensitivity, and impaired adipogenesis is implicated in insulin resistance. 4-Hydroxyderricin (4-HD), a phytochemical component of Angelica keiskei, possesses diverse biological properties such as anti-inflammatory, antidiabetic, and antitumor. In the present study, we investigated the...

article

Role of taurine in the pathogenesis of obesity

Shigeru Murakami

Molecular Nutrition & Food Research > 59 > 7 > 1353 - 1363

Taurine is a sulfur‐containing amino acid that is present in mammalian tissues in millimolar concentrations. Taurine is involved in a diverse array of biological and physiological functions, including bile salt conjugation, osmoregulation, membrane stabilization, calcium modulation, anti‐oxidation, and immunomodulation. The prevalence of obesity and being overweight continues to rise worldwide at...

article

Role of the osmolyte taurine on the folding of a model protein, hen egg white lysozyme, under a crowding condition

Yoshito Abe, Takatoshi Ohkuri, Sachiko Yoshitomi, Shigeru Murakami, more

Amino Acids > 2015 > 47 > 5 > 909-915

Taurine is one of the osmolytes that maintain the structure of proteins in cells exposed to denaturing environmental stressors. Recently, cryoelectron tomographic analysis of eukaryotic cells has revealed that their cytoplasms are crowded with proteins. Such crowding conditions would be expected to hinder the efficient folding of nascent polypeptide chains. Therefore, we examined the role of taurine...

article

Potential role of taurine in the prevention of diabetes and metabolic syndrome

Masato Imae, Toshiki Asano, Shigeru Murakami

Amino Acids > 2014 > 46 > 1 > 81-88

Metabolic syndrome is characterized by the cluster of a number of metabolic abnormalities in the presence of underlying insulin resistance. The prevalence of metabolic syndrome has steadily increased in all populations worldwide. Taurine (2-aminoethanesulfonic acid) is a sulfur-containing amino acid that is involved in a variety of physiological functions. Clinical and experimental studies show that...

article

Taurine and atherosclerosis

Shigeru Murakami

Amino Acids > 2014 > 46 > 1 > 73-80

Taurine is abundantly present in most mammalian tissues and plays a role in many important physiological functions. Atherosclerosis is the underlying mechanism of cardiovascular disease including myocardial infarctions, strokes and peripheral artery disease and remains a major cause of morbidity and mortality worldwide. Studies conducted in laboratory animal models using both genetic and dietary models...

article

Taurine improves obesity‐induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages

Shan Lin, Shizuka Hirai, Yuko Yamaguchi, Tsuyoshi Goto, more

Molecular Nutrition & Food Research > 57 > 12 > 2155 - 2165

ScopeIt is increasingly accepted that chronic inflammation is a feature of obesity. Obesity‐induced inflammation triggers enhanced recruitment of macrophages into the adipose tissue. Depending on their phenotype, macrophages can be designated either as pro‐inflammatory M1 macrophages or anti‐inflammatory M2 macrophages. We have therefore investigated the effects of taurine, a sulfated amino acid that...

article

Using the Objective Structured Assessment of Technical Skills (OSATS) global rating scale to evaluate the skills of surgical trainees in the operating room

Hiroaki Niitsu, Naoki Hirabayashi, Masanori Yoshimitsu, Takeshi Mimura, more

Surgery Today > 2013 > 43 > 3 > 271-275

Purpose The education of surgical trainees should be based on an accurate evaluation of their surgical skill levels. In our hospital, the Objective Structured Assessment of Technical Skills (OSATS) is used for this purpose. We conducted this study to demonstrate the validity and accuracy of the OSATS for assessing surgical skills in the operating room (OR) setting. Methods Between January, 2007...

article

Comparisons of multi b‐value DWI signal analysis with pathological specimen of breast cancer

Takayuki Tamura, Shuji Usui, Shigeru Murakami, Koji Arihiro, more

Magnetic Resonance in Medicine > 68 > 3 > 890 - 897

Previous studies have reported that the signal attenuation of diffusion weighted magnetic resonance imaging for tumor tissues displays a non‐monoexponential biexponential decay, and the apparent diffusion coefficients (ADCs) can be divided into a fast and slow diffusion component by using a simple biexponential decay model. The purpose of this study is to examine the non‐monoexponential character...

article

Memorial Sloan-Kettering Cancer Center Nomogram to predict the risk of non-sentinel lymph node metastasis in Japanese breast cancer patients

Tatsunari Sasada, Shigeru Murakami, Tsuyoshi Kataoka, Masahiro Ohara, more

Surgery Today > 2012 > 42 > 3 > 245-249

Purpose Axillary lymph node dissection (ALND) remains the standard procedure for breast cancer patients with sentinel lymph node (SLN) metastasis; however, additional nodal metastasis is detected in completion ALND in only about 50% of these patients. To identify the risk of non-SLN metastasis, the Memorial Sloan-Kettering Cancer Center (MSKCC) developed a nomogram. Many validation studies have been...

article

Auraptene regulates gene expression involved in lipid metabolism through PPARα activation in diabetic obese mice

Nobuyuki Takahashi, Mari Senda, Shan Lin, Tsuyoshi Goto, more

Molecular Nutrition & Food Research > 55 > 12 > 1791 - 1797

Scope: Peroxisome proliferator‐activated receptor‐α (PPARα) is a key regulator of circulating lipid level. Thus, various food‐derived compounds that activate PPARα as agonists have been screened and characterized. Methods and results: We investigated the effects of auraptene, a citrus‐derived compound serving as a PPARα agonist in vitro, on abnormalities in lipid and glucose metabolisms. In high‐fat‐diet...

article

Prevention of neointima formation by taurine ingestion after carotid balloon injury

Shigeru Murakami, Takanobu Sakurai, Yoshihisa Toda, Akihisa Morito, more

Vascular Pharmacology > 2010 > 53 > 3-4 > 177-184

The sulfur-containing amino acid, taurine, has been shown to ameliorate the vascular disorders. We examined the effects of taurine ingestion on intimal thickening following balloon injury. Balloon injury was induced in the left common carotid artery of Wistar rats. Taurine (3% (w/v)) was mixed in the drinking water from 2days prior to, until 14days after the induction of balloon injury. The ratio...

article

Effects of Citrus Auraptene (7-Geranyloxycoumarin) on Hepatic Lipid Metabolism in Vitro and in Vivo

Koji Nagao, Naomi Yamano, Bungo Shirouchi, Nao Inoue, more

Journal of Agricultural and Food Chemistry > 2010 > 58 > 16 > 9028 - 9032

article

14. Re-appearance of ABRs after removal of a large CPA meningioma

Yojiro Seki, Naoyuki Samejima, Nobumasa Kuwana, Shigeru Murakami, more

Clinical Neurophysiology > 2010 > 121 > 7 > e22

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Search results for: Shigeru Murakami

Taurine attenuates the development of hepatic steatosis through the inhibition of oxidative stress in a model of nonalcoholic fatty liver disease in vivo and in vitro

Mass spectrometry-based metabolomics to identify taurine-modified metabolites in heart

The physiological and pathophysiological roles of taurine in adipose tissue in relation to obesity

Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARγ Activation

Xanthoangelol and 4‐hydroxyderrcin suppress obesity‐induced inflammatory responses

Taurine ameliorates cholesterol metabolism by stimulating bile acid production in high‐cholesterol‐fed rats

Taurine as the Nutritional Factor for the Longevity of the Japanese Revealed by a World-Wide Epidemiological Survey

4-Hydroxyderricin, as a PPARγ Agonist, Promotes Adipogenesis, Adiponectin Secretion, and Glucose Uptake in 3T3-L1 Cells

Role of taurine in the pathogenesis of obesity

Role of the osmolyte taurine on the folding of a model protein, hen egg white lysozyme, under a crowding condition

Potential role of taurine in the prevention of diabetes and metabolic syndrome

Taurine and atherosclerosis

Taurine improves obesity‐induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages

Using the Objective Structured Assessment of Technical Skills (OSATS) global rating scale to evaluate the skills of surgical trainees in the operating room

Comparisons of multi b‐value DWI signal analysis with pathological specimen of breast cancer

Memorial Sloan-Kettering Cancer Center Nomogram to predict the risk of non-sentinel lymph node metastasis in Japanese breast cancer patients

Auraptene regulates gene expression involved in lipid metabolism through PPARα activation in diabetic obese mice

Prevention of neointima formation by taurine ingestion after carotid balloon injury

Effects of Citrus Auraptene (7-Geranyloxycoumarin) on Hepatic Lipid Metabolism in Vitro and in Vivo

14. Re-appearance of ABRs after removal of a large CPA meningioma

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