Search results for: Shuji Shimizu

Items from 1 to 20 out of 107 results

article

Ivabradine preserves dynamic sympathetic control of heart rate despite inducing significant bradycardia in rats

Toru Kawada, Shuji Shimizu, Kazunori Uemura, Yohsuke Hayama, more

The Journal of Physiological Sciences > 2019 > 69 > 2 > 211-222

Ivabradine is a selective bradycardic agent that inhibits hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. HCN channels play a key role in mediating the positive chronotropic response to sympathetic nerve stimulation (SNS). We examined whether ivabradine would interfere with dynamic sympathetic control of heart rate (HR). The effect of intravenous ivabradine (2 mg/kg, n = 7) or...

article

Role of SpyGlass-DStm in the preoperative assessment of pancreatic intraductal papillary mucinous neoplasm involving the main pancreatic duct

Takao Ohtsuka, Yoshitaka Gotoh, Yohei Nakashima, Yoshifumi Okayama, more

Pancreatology > 2018 > 18 > 5 > 566-571

It is often difficult to determine an adequate resection line during pancreatectomy for intraductal papillary mucinous neoplasm involving the main pancreatic duct during partial pancreatectomy. The aim of this study was to evaluate the usefulness of improved peroral pancreatoscopy using SpyGlass-DS^tm in the preoperative assessment of intraductal papillary mucinous neoplasm involving the main pancreatic...

article

Lumped parameter model for hemodynamic simulation of congenital heart diseases

Shuji Shimizu, Dai Une, Toru Kawada, Yohsuke Hayama, more

The Journal of Physiological Sciences > 2018 > 68 > 2 > 103-111

The recent development of computer technology has made it possible to simulate the hemodynamics of congenital heart diseases on a desktop computer. However, multi-scale modeling of the cardiovascular system based on computed tomographic and magnetic resonance images still requires long simulation times. The lumped parameter model is potentially beneficial for real-time bedside simulation of congenital...

article

Wave reflection correlates with pulmonary vascular wall thickening in rats with pulmonary arterial hypertension

Masafumi Fukumitsu, Toru Kawada, Shuji Shimizu, Michael J. Turner, more

International Journal of Cardiology > 2017 > 249 > C > 396-401

Wave reflection is enhanced in patients with pulmonary arterial hypertension (PAH), which may be derived from a mismatch of pulmonary artery (PA) impedance between proximal and distal sites of arteries. Whether enhanced wave reflection correlates with histological remodeling remains unknown, partly because lung biopsy is not clinically recommended for PAH patients due to substantial risks of mortality...

article

Peripheral versus central effect of intravenous moxonidine on rat carotid sinus baroreflex-mediated sympathetic arterial pressure regulation

Toru Kawada, Shuji Shimizu, Hiromi Yamamoto, Tadayoshi Miyamoto, more

Life Sciences > 2017 > 190 > C > 103-109

Moxonidine is a centrally acting antihypertensive agent with a selectivity to I₁-imidazoline receptors higher than that to α₂-adrenergic receptors. The present study aimed to quantify a peripheral effect of moxonidine on carotid sinus baroreflex-mediated sympathetic arterial pressure (AP) regulation separately from its central effect.In eight anesthetized Wistar rats, changes in efferent sympathetic...

article

Correction to: Physiological insights of recent clinical diagnostic and therapeutic technologies for cardiovascular diseases

Kenji Shigemi, Soichiro Fuke, Dai Une, Keita Saku, more

The Journal of Physiological Sciences > 2018 > 68 > 2 > 203-203

The article Physiological insights of recent clinical diagnostic and therapeutic technologies for cardiovascular diseases, written by Kenji Shigemi, Soichiro Fuke, Dai Une, Keita Saku, Shuji Shimizu, Toru Kawada, Toshiaki Shishido, Kenji Sunagawa and Masaru Sugimachi, was originally published Online First without open access.

article

Clinical significance of circumportal pancreas, a rare congenital anomaly, in pancreatectomy

Takao Ohtsuka, Yasuhisa Mori, Kousei Ishigami, Takaaki Fujimoto, more

The American Journal of Surgery > 2017 > 214 > 2 > 267-272

Circumportal pancreas is a rare congenital pancreatic anomaly. The aim of this study was to clarify the clinical characteristics of patients with circumportal pancreases undergoing pancreatectomy.The medical records of 508 patients who underwent pancreatectomy were retrospectively reviewed. The prevalence of circumportal pancreas and related anatomical variations were assessed. Surgical procedures...

article

Physiological insights of recent clinical diagnostic and therapeutic technologies for cardiovascular diseases

Kenji Shigemi, Soichiro Fuke, Dai Une, Keita Saku, more

The Journal of Physiological Sciences > 2017 > 67 > 6 > 655-672

Diagnostic and therapeutic methods for cardiovascular diseases continue to be developed in the 21st century. Clinicians should consider the physiological characteristics of the cardiovascular system to ensure successful diagnosis and treatment. In this review, we focus on the roles of cardiovascular physiology in recent diagnostic and therapeutic technologies for cardiovascular diseases. In the first...

article

Desipramine increases cardiac parasympathetic activity via α2-adrenergic mechanism in rats

Toru Kawada, Tsuyoshi Akiyama, Shuji Shimizu, Masafumi Fukumitsu, more

Autonomic Neuroscience > 2017 > 205 > C > 21-25

Desipramine (DMI) is a blocker of neuronal norepinephrine (NE) uptake transporter. Although intravenous DMI has been shown to cause centrally-mediated sympathoinhibition and peripheral NE accumulation, its parasympathetic effect remains to be elucidated. We hypothesized that intravenous DMI activates the cardiac vagal nerve via an α₂-adrenergic mechanism. Using a cardiac microdialysis technique, changes...

article

Cardiac vagal control in a knock-in mouse model of dilated cardiomyopathy with a troponin mutation

Dong-Yun Zhan, Cheng-Kun Du, Tsuyoshi Akiyama, Sachio Morimoto, more

Autonomic Neuroscience > 2017 > 205 > C > 33-40

The aim of this study was to evaluate cardiac vagal nerve activity and identify the abnormality of cardiac vagal control in heart failure caused by dilated cardiomyopathy (DCM) using a knock-in mouse model with a ΔK210 mutation in the cardiac troponin T gene. The effects of electrical stimulation of the cervical vagal nerve at 5 and 10Hz (peripheral vagal control) and α₂-adrennoceptor stimulation...

article

Laparoscopic surgery for congenital biliary dilatation: a single-institution experience

Mohammed Y. F. Aly, Yasuhisa Mori, Yoshihiro Miyasaka, Takao Ohtsuka, more

Surgery Today > 2018 > 48 > 1 > 44-50

Purpose Laparoscopic surgery as a treatment for congenital biliary dilatation is uncommon. We herein present a series of laparoscopic surgeries for congenital biliary dilatation performed in our institution and review our experience with this approach over a long period of time. Methods Medical records of 36 consecutive patients who underwent laparoscopic surgery for congenital biliary dilatation...

article

Reply to Letter

Shuji Shimizu, Takao Ohtsuka, Masao Tanaka

Digestive Endoscopy > 29 > 2 > 237 - 238

article

Sodium ion transport participates in non-neuronal acetylcholine release in the renal cortex of anesthetized rabbits

Shuji Shimizu, Tsuyoshi Akiyama, Toru Kawada, Yusuke Sata, more

The Journal of Physiological Sciences > 2017 > 67 > 5 > 587-593

This study examined the mechanism of release of endogenous acetylcholine (ACh) in rabbit renal cortex by applying a microdialysis technique. In anesthetized rabbits, a microdialysis probe was implanted into the renal cortex and perfused with Ringer’s solution containing high potassium concentration, high sodium concentration, a Na⁺/K⁺-ATPase inhibitor (ouabain), or an epithelial Na⁺ channel blocker...

article

Systematic understanding of acute effects of intravenous guanfacine on rat carotid sinus baroreflex-mediated sympathetic arterial pressure regulation

Toru Kawada, Shuji Shimizu, Michael J. Turner, Masafumi Fukumitsu, more

Life Sciences > 2016 > 149 > C > 72-78

To assess the acute effects of intravenous guanfacine, an α_2A-adrenergic agonist, on sympathetic outflow from the central nervous system and on sympathetic arterial pressure (AP) response.In anesthetized Wistar Kyoto rats, carotid sinus baroreceptor regions were isolated. Changes in electrical sympathetic nerve activity (SNA) and AP in response to a baroreceptor pressure input were examined before...

article

Remote transmission of live endoscopy over the Internet: Report from the 87th Congress of the Japan Gastroenterological Endoscopy Society

Shuji Shimizu, Takao Ohtsuka, Shunichi Takahata, Eishi Nagai, more

Digestive Endoscopy > 28 > 1 > 92 - 97

Live demonstration of endoscopy is one of the most attractive and useful methods for education and is often organized locally in hospitals. However, problems have been apparent in terms of cost, preparation, and potential risks to patients. Our aim was to evaluate a new approach to live endoscopy whereby remote hospitals are connected by the Internet for live endoscopic demonstrations. Live endoscopy...

article

Partial cavopulmonary assist from the inferior vena cava to the pulmonary artery improves hemodynamics in failing Fontan circulation: a theoretical analysis

Shuji Shimizu, Toru Kawada, Dai Une, Masafumi Fukumitsu, more

The Journal of Physiological Sciences > 2016 > 66 > 3 > 249-255

Cavopulmonary assist (CPA) for failing Fontan patients remains a challenging issue in the clinical setting. To evaluate the effectiveness of a partial CPA from the inferior vena cava (IVC) to the pulmonary artery (PA), we performed a theoretical analysis using a computational model of the Fontan circulation. Cardiac chambers and vascular systems were described as the time-varying elastance model and...

article

Hybrid stage I palliation for hypoplastic left heart syndrome has no advantage on ventricular energetics: a theoretical analysis

Shuji Shimizu, Toru Kawada, Dai Une, Toshiaki Shishido, more

Heart and Vessels > 2016 > 31 > 1 > 105-113

A hybrid procedure combining bilateral pulmonary artery banding with ductal stenting has recently been used as stage I palliation for hypoplastic left heart syndrome. However, the advantage of the hybrid procedure over the Norwood procedure on ventricular energetics remains unclear. To clarify this, we performed a computational analysis with a combination of time-varying elastance chamber model and...

article

Thoracic endovascular aortic repair for patent ductus arteriosus in an elderly patient with congestive heart failure

Gentaro Kato, Mikizo Nakai, Noriyuki Tokunaga, Shuji Shimizu, more

General Thoracic and Cardiovascular Surgery > 2016 > 64 > 5 > 280-282

In elderly patients, open surgery for patent ductus arteriosus (PDA) is more difficult than that in children and often requires a cardiopulmonary bypass. We report the case of a 67-year-old patient with a PDA that was successfully treated with thoracic endovascular aortic repair (TEVAR). The patient was diagnosed with congestive heart failure (ejection fraction, 36 %) and PDA (9.7 mm in diameter)...

article

Reduced‐port laparoscopic restorative proctocolectomy without diverting ileostomy

Takashi Ueki, Tatsuya Manabe, Kinuko Nagayoshi, Kosuke Yanai, more

Asian Journal of Endoscopic Surgery > 8 > 4 > 487 - 490

IntroductionWe introduced a reduced‐port procedure for laparoscopic restorative proctocolectomy without diverting ileostomy for patients with familial adenomatous polyposis and ulcerative colitis. Materials and Surgical TechniqueA multichannel port was inserted through a 2.5‐cm umbilical incision. A 12‐mm port in the right lower abdomen and a 3‐ or 5‐mm port were also employed. A proctocolectomy...

article

Open-loop characteristics of the arterial baroreflex after blockade of unmyelinated baroreceptors with resiniferatoxin

Michael J. Turner, Toru Kawada, Shuji Shimizu, Masafumi Fukumitsu, more

Autonomic Neuroscience > 2015 > 193 > C > 38-43

Arterial baroreceptors can be divided into two categories dependent on whether their axons are myelinated (A-fiber) or unmyelinated (C-fiber). We investigated the effect of periaxonal resiniferatoxin (RTX), a blocker of C-fiber baroreceptor activity, on the open-loop static characteristics of the arterial baroreflex. The baroreceptor region of the right aortic depressor nerve was isolated, and intra-baroreceptor...

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Search results for: Shuji Shimizu

Ivabradine preserves dynamic sympathetic control of heart rate despite inducing significant bradycardia in rats

Role of SpyGlass-DStm in the preoperative assessment of pancreatic intraductal papillary mucinous neoplasm involving the main pancreatic duct

Lumped parameter model for hemodynamic simulation of congenital heart diseases

Wave reflection correlates with pulmonary vascular wall thickening in rats with pulmonary arterial hypertension

Peripheral versus central effect of intravenous moxonidine on rat carotid sinus baroreflex-mediated sympathetic arterial pressure regulation

Correction to: Physiological insights of recent clinical diagnostic and therapeutic technologies for cardiovascular diseases

Clinical significance of circumportal pancreas, a rare congenital anomaly, in pancreatectomy

Physiological insights of recent clinical diagnostic and therapeutic technologies for cardiovascular diseases

Desipramine increases cardiac parasympathetic activity via α2-adrenergic mechanism in rats

Cardiac vagal control in a knock-in mouse model of dilated cardiomyopathy with a troponin mutation

Laparoscopic surgery for congenital biliary dilatation: a single-institution experience

Reply to Letter

Sodium ion transport participates in non-neuronal acetylcholine release in the renal cortex of anesthetized rabbits

Systematic understanding of acute effects of intravenous guanfacine on rat carotid sinus baroreflex-mediated sympathetic arterial pressure regulation

Remote transmission of live endoscopy over the Internet: Report from the 87th Congress of the Japan Gastroenterological Endoscopy Society

Partial cavopulmonary assist from the inferior vena cava to the pulmonary artery improves hemodynamics in failing Fontan circulation: a theoretical analysis

Hybrid stage I palliation for hypoplastic left heart syndrome has no advantage on ventricular energetics: a theoretical analysis

Thoracic endovascular aortic repair for patent ductus arteriosus in an elderly patient with congestive heart failure

Reduced‐port laparoscopic restorative proctocolectomy without diverting ileostomy

Open-loop characteristics of the arterial baroreflex after blockade of unmyelinated baroreceptors with resiniferatoxin

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