Search results for: Riki Okita

Items from 1 to 20 out of 23 results

article

PD-L1 overexpression is partially regulated by EGFR/HER2 signaling and associated with poor prognosis in patients with non-small-cell lung cancer

Riki Okita, Ai Maeda, Katsuhiko Shimizu, Yuji Nojima, more

Cancer Immunology, Immunotherapy > 2017 > 66 > 7 > 865-876

Immunocheckpoint inhibitors targeting the programmed cell death-1 (PD-1) and PD-1 ligand 1 (PD-L1) axis have shown promising results in patients with non-small-cell lung cancer (NSCLC). Recent research has shown that epidermal growth factor receptor (EGFR) signaling affects PD-L1 expression in NSCLC cells; however, the mechanism regulating PD-L1 expression in tumor cells remains unclear. Using immunohistochemistry,...

chapter

Adoptive Immunotherapy of Cancer Using Autologous Lymphocytes

Yoshiyuki Yamaguchi, Riki Okita, Akiko Emi, Katsuji Hironaka, more

Cancer Growth and Progression > Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures > Biological Therapy > 285-294

Adoptive immunotherapy (AIT) of cancer using lymphocytes is a highly promising modality for eradicating cancer. The AIT strategy is less dependently of cancer-associated immune dysfunction, which exists in tumor-bearing host. The cloning of interleukin-2 (IL-2) has facilitated to manipulate and to propagate effector cells. Lymphokine-activated killer (LAK) cells and tumor-infiltrating lymphocytes...

article

MHC class I chain-related molecule A and B expression is upregulated by cisplatin and associated with good prognosis in patients with non-small cell lung cancer

Riki Okita, Takuro Yukawa, Yuji Nojima, Ai Maeda, more

Cancer Immunology, Immunotherapy > 2016 > 65 > 5 > 499-509

MHC class I chain-related molecule A and B (MICA/B) are NK group 2 member D (NKG2D) ligands, which are broadly expressed in transformed cells. Both DNA damage-induced ataxia-telangiectasia-mutated (ATM)- and ATM and Rad3-related protein kinases (ATM–ATR) signaling and oncogene-induced PI3K–AKT signaling regulate the expression of NKG2D ligands, which promote NK cell-mediated cytotoxicity via NKG2D–NKG2D...

article

Pneumatosis intestinalis after gefitinib therapy for pulmonary adenocarcinoma: a case report

Ai Maeda, Masao Nakata, Katsuhiko Shimizu, Takuro Yukawa, more

World Journal of Surgical Oncology > 2016 > 14 > 1 > 1-4

Background Pneumatosis intestinalis (PI) is defined as the presence of gas in the bowel wall and is a relatively rare finding. PI has been associated with various pathological conditions and medications. Although several chemotherapeutic agents and molecular targeted therapy agents are reported to be associated with PI, there have been few reports describing the association between the anti-epidermal...

article

Clinical significance of dual-time-point 18F-FDG PET imaging in resectable non-small cell lung cancer

Katsuhiko Shimizu, Riki Okita, Shinsuke Saisho, Takuro Yukawa, more

Annals of Nuclear Medicine > 2015 > 29 > 10 > 854-860

Objective The maximal standardized uptake value (SUVmax) of pulmonary lesions on dual-time-point (DTP) fluorodeoxyglucose positron emission tomography (FDG-PET) has been shown to be useful for differentiation between malignant and non-malignant pulmonary lesions, and also to be of value for intrathoracic nodal staging of non-small cell lung cancer (NSCLC). However, a few NSCLC lesions have been found...

article

Cyclooxygenase-2 expression is a prognostic biomarker for non-small cell lung cancer patients treated with adjuvant platinum-based chemotherapy

Katsuhiko Shimizu, Takuro Yukawa, Riki Okita, Shinsuke Saisho, more

World Journal of Surgical Oncology > 2015 > 13 > 1 > 1-7

Background Adjuvant chemotherapy after the resection of stage IB-IIIA non-small cell lung cancer (NSCLC) is now the standard of care based on large-scale phase III trials and a meta-analysis. However, chemotherapy has plateaued in terms of its efficacy, and the search for treatment prediction biomarkers is imperative for the further identification of treatable subgroups. Therefore, we investigated...

article

Preoperative neutrophil/lymphocyte ratio and prognostic nutritional index predict survival in patients with non-small cell lung cancer

Katsuhiko Shimizu, Riki Okita, Shinsuke Saisho, Ai Maeda, more

World Journal of Surgical Oncology > 2015 > 13 > 1 > 1-8

Background The immunological status, consisting of “inflammation status” and “nutritional condition,” is important for the survival of patients with various cancers, including non-small cell lung cancer (NSCLC). The neutrophil/lymphocyte ratio (NLR) reflects the inflammation status, and the prognostic nutritional index (PNI) reflects the immunological nutritional condition. In the present study, the...

article

A case report of intrapulmonary schwannoma

Takuro Yukawa, Katsuhiko Shimizu, Yuji Hirami, Riki Okita, more

General Thoracic and Cardiovascular Surgery > 2014 > 62 > 4 > 252-254

A 38-year-old man without any symptoms was admitted to our institution because of an abnormal shadow found incidentally on a chest X-ray. Chest computed tomography showed a round mass in the lingular segment of the left upper lobe. Lingular segmentectomy was performed, and the histopathological diagnosis was intrapulmonary schwannoma. Immunohistochemical staining revealed a positive result for S-100...

article

Role of 2-[18F]fluoro-2-deoxyglucose positron emission tomography in preoperative management of solid-type small-sized lung cancer

Shinsuke Saisho, Koichiro Yasuda, Ai Maeda, Takuro Yukawa, more

Annals of Nuclear Medicine > 2013 > 27 > 6 > 515-522

Objective 2-[18F]Fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is routinely used for the diagnosis of primary lung cancer. However, the role of FDG-PET in the diagnosis and staging of small-sized lung cancer has not been sufficiently evaluated. The purpose of this study was to determine the utility of FDG-PET for preoperative staging of solid-type small-sized lung cancer manifesting...

article

Heterogeneity of the EGFR mutation status between the primary tumor and metastatic lymph node and the sensitivity to EGFR tyrosine kinase inhibitor in non-small cell lung cancer

Katsuhiko Shimizu, Takuro Yukawa, Yuji Hirami, Riki Okita, more

Targeted Oncology > 2013 > 8 > 4 > 237-242

The purpose of this study was to clarify the distribution of epidermal growth factor receptor (EGFR) mutations between primary tumors (PT) and metastatic lymph node (MLN) in patients with resected non-small cell lung cancer (NSCLC) and to identify a better predictive marker of the response to EGFR tyrosine kinase inhibitor (EGFR-TKI). We conducted a retrospective review of the data of 70 lung cancer...

article

Unknown primary large cell neuroendocrine carcinoma (LCNEC) in the mediastinum

Ai Maeda, Masao Nakata, Kouichiro Yasuda, Takuro Yukawa, more

General Thoracic and Cardiovascular Surgery > 2013 > 61 > 9 > 542-545

Unknown primary large cell neuroendocrine carcinoma (LCNEC) in the mediastinum is extremely rare. In this report, we present a case of a 53-year-old man with superior vena cava (SVC) syndrome who developed LCNEC in the middle mediastinum. His chief complaint was facial edema. Chest X-ray revealed an abnormal shadow in the right upper mediastinum. Computed tomography (CT) scan of the chest revealed...

article

Successful perioperative management for a breast cancer patient with Bernard–Soulier syndrome

Riki Okita, Jun Hihara, Kazuo Konishi, Akihiko Osaki, more

Breast Cancer > 2012 > 19 > 1 > 88-92

We herein report the first case of a Bernard–Soulier syndrome (BSS) patient undergoing a surgical procedure for breast cancer. BSS is a rare hereditary thrombocytopathy associated with defects of the platelet glycoprotein complex glycoprotein Ib/V/IX and characterized by large platelets, thrombocytopenia, and severe bleeding symptoms. Because of the rarity of BSS, there are as yet no defined protocols...

article

High expression of GCLC is associated with malignant melanoma of low oxidative phenotype and predicts a better prognosis

Dimitrios Mougiakakos, Riki Okita, Takashi Ando, Christoph Dürr, more

Journal of Molecular Medicine > 2012 > 90 > 8 > 935-944

Reactive oxygen species (ROS) are strongly implicated in melanoma development, and treatment with antioxidants has shown efficacy in suppressing malignant transition and progression. Here, we investigated the significance of the glutamate-l-cysteine ligase catalytic subunit (GCLC) expression, a key regulator of glutathione synthesis, for malignant melanoma. A large set of melanoma cell lines (n =...

article

Successful management of multiple esophagorespiratory fistulas using two types of stent: Report of a case

Yoichi Hamai, Jun Hihara, Manabu Emi, Riki Okita, more

Surgery Today > 2011 > 41 > 4 > 560-562

We herein describe a 41-year-old man with esophageal cancer who developed three esophagorespiratory fistulas (ERFs) that were successfully treated using one esophageal and three airway stents. A self-expandable metallic stent (SEMS) was initially inserted into the esophagus to close an ERF in the right bronchus. However, two new ERFs developed in the trachea and the left main bronchus 3 months later...

article

T cell recognition of HLA‐A2 restricted tumor antigens is impaired by the oncogene HER2

Kousaku Mimura, Takashi Ando, Isabel Poschke, Dimitrios Mougiakakos, more

International Journal of Cancer > 128 > 2 > 390 - 401

The HER2 oncogene is frequently over‐expressed in human cancers and a promising target for immune therapy. Previous studies have shown that over‐expression of mouse or rat HER2 leads to markedly reduced levels of major histocompatibility complex (MHC) class I and molecules of the antigen processing and presentation machinery (APM), thus resulting in a phenotype promoting tumor escape from the immune...

article

Suggestive synchronous triple squamous cell carcinoma of the lung in the same lobe

Riki Okita, Katsuhiko Shimizu, Takeshi Mimura, Yoshihiro Miyata, more

General Thoracic and Cardiovascular Surgery > 2010 > 58 > 8 > 427-430

We report a case of suggestive synchronous triple squamous cell carcinoma (Sq) of the lung that occurred in the same lobe. Under a clinical diagnosis of triple lung cancer, lobectomy was performed. Pathological examination revealed two well-differentiated Sq and one poorly differentiated Sq. The analysis of epidermal growth factor receptor-tyrosine kinase mutations showed no mutation in each tumor...

article

Use of entecavir to prevent hepatitis B virus reactivation during cytotoxic chemotherapy for solid malignancy

Riki Okita, Mamoru Takahashi, Hiroyuki Narahara, Yuichi Sanada, more

Clinical Journal of Gastroenterology > 2009 > 2 > 3 > 214-217

Reactivation of hepatitis B virus (HBV) infection is a frequent complication of cytotoxic chemotherapy that includes steroids. International studies have shown that lamivudine reduces the incidence and severity of hepatitis in HBV carriers undergoing chemotherapy to treat malignancies. However, prolonged lamivudine therapy is associated with an increased risk of drug-resistant tyrosine-methionine-aspartate-aspartate...

article

Pharmacokinetic analysis of a combined chemoendocrine treatment with paclitaxel and toremifene for metastatic breast cancer

Toshiaki Saeki, Atsushi Okita, Kenjiro Aogi, Tomokazu Kakishita, more

Breast Cancer > 2009 > 16 > 2 > 113-120

Background Multidrug resistance protein could be a target for improving the efficacy of paclitaxel (PXL). Toremifene (TOR) may moderate P-gp-related drug resistance in vitro. Some P-gp moderators may change the pharmacokinetic parameters of PXL in vivo. A pharmacokinetic (PK) study in metastatic breast cancer patients (MBC) was conducted to determine the safety and efficacy of PXL and TOR. Method...

article

Functional inactivation of CD4+CD25^high regulatory T cells using low dose human/mouse chimeric anti-CD25 monoclonal antibody enhanced lymphokine-activated killer cells activity

Riki Okita, Yoshiyuki Yamaguchi, Masahiro Ohara, Takuhiro Ikeda, more

Targeted Oncology > 2008 > 3 > 4 > 227-234

Functional modulation of regulatory T cells (T-regs) is one possible approach to cancer immunotherapy. In this study, we investigated whether low-dose basiliximab, a chimeric anti-CD25 monoclonal antibody, could suppress the T-regs function not by depletion but by inactivation, and increase immune responses. Peripheral blood mononuclear cells from healthy donors and patients with malignancy were collected...

article

Non-palpable ductal carcinomain situ (DCIS) with microinvasion arising in a radial scar presenting with spiculation alone on mammograms: A case report

Atsushi Okita, Shozo Ohsumi, Shigemitsu Takashima, Riki Okita, more

Breast Cancer > 2006 > 13 > 1 > 107-111

A case of ductal carcinomain situ (DCIS) with microinvasion arising in a radial scar of the breast is presented. A 57-year-old woman visited our hospital with bloody discharge from her left nipple. There were no abnormal findings on cytology, carcinoembryonic antigen (CEA) level of nipple discharge was <500 ng/ml, and mammograms were normal. After 2 years of careful periodic follow-up, spiculation...

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Search results for: Riki Okita

PD-L1 overexpression is partially regulated by EGFR/HER2 signaling and associated with poor prognosis in patients with non-small-cell lung cancer

Adoptive Immunotherapy of Cancer Using Autologous Lymphocytes

MHC class I chain-related molecule A and B expression is upregulated by cisplatin and associated with good prognosis in patients with non-small cell lung cancer

Pneumatosis intestinalis after gefitinib therapy for pulmonary adenocarcinoma: a case report

Clinical significance of dual-time-point 18F-FDG PET imaging in resectable non-small cell lung cancer

Cyclooxygenase-2 expression is a prognostic biomarker for non-small cell lung cancer patients treated with adjuvant platinum-based chemotherapy

Preoperative neutrophil/lymphocyte ratio and prognostic nutritional index predict survival in patients with non-small cell lung cancer

A case report of intrapulmonary schwannoma

Role of 2-[18F]fluoro-2-deoxyglucose positron emission tomography in preoperative management of solid-type small-sized lung cancer

Heterogeneity of the EGFR mutation status between the primary tumor and metastatic lymph node and the sensitivity to EGFR tyrosine kinase inhibitor in non-small cell lung cancer

Unknown primary large cell neuroendocrine carcinoma (LCNEC) in the mediastinum

Successful perioperative management for a breast cancer patient with Bernard–Soulier syndrome

High expression of GCLC is associated with malignant melanoma of low oxidative phenotype and predicts a better prognosis

Successful management of multiple esophagorespiratory fistulas using two types of stent: Report of a case

T cell recognition of HLA‐A2 restricted tumor antigens is impaired by the oncogene HER2

Suggestive synchronous triple squamous cell carcinoma of the lung in the same lobe

Use of entecavir to prevent hepatitis B virus reactivation during cytotoxic chemotherapy for solid malignancy

Pharmacokinetic analysis of a combined chemoendocrine treatment with paclitaxel and toremifene for metastatic breast cancer

Functional inactivation of CD4+CD25^high regulatory T cells using low dose human/mouse chimeric anti-CD25 monoclonal antibody enhanced lymphokine-activated killer cells activity

Non-palpable ductal carcinomain situ (DCIS) with microinvasion arising in a radial scar presenting with spiculation alone on mammograms: A case report

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