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Background and Purpose
Obesity is a risk factor for the development of chronic kidney disease independent of diabetes, hypertension and other co‐morbidities. Obesity‐associated nephropathy is linked to dysregulation of the cell energy sensor AMP‐activated protein kinase (AMPK). We aimed here to assess whether impairment of AMPK activity may cause renal arterial dysfunction in obesity and to evaluate...
Metabolic syndrome (MS) individuals have a higher risk of developing chronic kidney disease through unclear pathogenic mechanisms. MS has been also related with higher nephrolithiasis prevalence. To establish the influence of MS on renal function, we designed a murine model of combined metabolic syndrome and hyperoxaluria. Four groups of male Sprague–Dawley rats were established: (1) control group...
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