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On the basis of remarkable anticancer profile of s‐triazine nucleus, a new series of 2‐methoxy‐4‐(3‐morpholino‐5‐(arylamino)phenoxy)benzaldehyde derivatives 11 a–u was prepared and evaluated for in vitro antiproliferative activity against eight diverse human cancer cell lines (Capan‐1, HCT‐116, LN229, NCI‐H460, DND‐41, HL‐60, K562 and Z138). Compounds 11 o, 11 r and 11 s were the most potent anticancer...
Benzophenones (BPs) and their hydroxylated derivatives exhibited low estrogenic activity in human breast cancer cell. However, the available reported data are insufficient to describe structure modification relationship of these molecules that can be developed as a potential breast cancer drug. In this work, we present a 240-ns molecular dynamics (MD) simulation analysis on the conformational flexibility...
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