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Several organic solvents have anticonvulsant or convulsant actions depending on the dose and exposure time. To study if there is a structure-activity relationship for organic solvents as anticonvulsant agents we subjected independent groups of mice to a single 30-min exposure session to inhale n-hexane, cyclohexane, benzene (8000ppm each), toluene (500–6000ppm), m-xylene (1000–6000ppm), ethylbenzene...
Rationale Toluene is a misused inhalant with hallucinogenic properties and complex effects. Toluene blocks N-methyl-d-aspartate (NMDA) receptors, releases dopamine (DA), and modifies several neurotransmitter levels; nonetheless, the mechanism by which it produces hallucinations is not well characterized. Objectives This study aims (a) to study toluene’s effects on the 5-HT2A-mediated head-twitch...
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