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Key points
This is the first long‐term human clinical trial to report on effects of nicotinamide riboside (NR) on skeletal muscle mitochondrial function, content and morphology.
NR supplementation decreases nicotinamide phosphoribosyltransferase (NAMPT) protein abundance in skeletal muscle.
NR supplementation does not affect NAD metabolite concentrations in skeletal muscle.
Respiration, distribution...
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