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Gadolinium(Gd)-haltige Kontrastmittel (KM) werden seit 1988 in der klinischen MRT-Routinediagnostik weltweit eingesetzt. Dabei wurden alle in der Routine verwendeten Kontrastmittel in der zugelassenen Dosierung hinsichtlich Verträglichkeit, Nebenwirkungsprofil und diagnostischer Wirksamkeit lange Zeit als sicher eingestuft. Mit der Beobachtung der nephrogenen systemischen Fibrose (NSF) und der Gd-Retention...