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Rationale Acute pharmacological studies implicate μ-opioid receptors (MORs) in the parabrachial nucleus (PBN) of the brainstem in modulating eating. The long-term effects of preventing the cellular function of parabrachial MORs on food consumption remain to be elucidated. Objectives To determine whether (1) chronic inhibition of MOR-mediated G-protein coupling in the PBN of rats would persistently...