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Ion channels and transporters regulate transmembrane electrochemical gradients to control cardiomyocyte depolarization/repolarization and cell excitability. Importantly, ion channel and transporter function depends on proper expression and localization within specific cellular membrane domains. Ankyrins are a family of proteins that are widely expressed in vertebrate tissues including heart. Recently,...
Electrical and structural remodeling during the progression of cardiovascular disease is associated with adverse outcomes subjecting affected patients to overt heart failure (HF) and/or sudden death. Dysfunction in integral membrane protein trafficking has long been linked with maladaptive electrical remodeling. However, little is known regarding the molecular identity or function of these intracellular...
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