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Anticonvulsant 4,5 dihydro-3,3-dialkyl-2(3H)-furanones act at sites on the GABAA receptor complex. Novel 5-substituted esters and homologous ester and amido derivatives of 4,5 dihydro-3,3-diethyl-2(3H)-furanone were synthesized and evaluated for anticonvulsant activity in rodents and for affinity to a site on the GABAA receptor complex ([3H]TBOB). The data suggest that the esters and the homologs...