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As a thrombus grows in a stenosis, the lumen narrows producing very high shear rates as blood velocities increase. Binding platelets are subjected to drag forces exceeding 10,000 pN. These forces could be balanced by 100 simultaneous 100 pN GPIbα-vWF-A1 bonds. The density of GPIbα ligands on platelets is sufficiently high; however, platelet capture under high shear would require the vWF-A1 density...