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In athymic mice we have developed a model of long-term human PTH hypersecretion, using xenotransplantation of respectively parathyroid gland fragments obtained from patients with primary (1°) or secondary (2°) uremic hyperparathyroidism (HPT), and parathyroid cells maintained in culture from patients with 2° uremic HPT. Both grafted parathyroid tissue fragments and cultured cells induced prolonged...