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Research on arterial chemoreceptors, particularly on the carotid body, has been fruitful in the last fifty years, to which this review is addressed. The functional anatomy of the organ appears to be well established. The biophysical bases by which glomus cells transduce chemical changes in the milieu intérieur (hypoxia, hypercapnia, acidosis) into electrical and biochemical changes in glomus cells...
Hydrogen sulfide has been found to relax vascular smooth muscle, to function as a neuroprotectant molecule in the CNS in an extensive corpus of literature. However, very little has been reported regarding the effect of H 2 S on airway smooth muscle. Just as relaxation of vascular smooth muscle would be a benefit for hypertensive subjects, relaxation of airways smooth muscle would be helpful...
The carotid body is a major arterial chemoreceptor that senses low O 2 tension, high CO 2 tension and low pH in the arterial blood. It is generally believed that neurotransmitters, including acetylcholine (ACh), participate in the genesis of afferent neural output from the carotid body and modulate the function of chemoreceptor cells (glomus cells). Previous pharmacological studies...
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