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Nearly all prostate cancer deaths are from metastatic castration-resistant prostate cancer (mCRPC), but there have been few whole-genome sequencing (WGS) studies of this disease state. We performed linked-read WGS on 23 mCRPC biopsy specimens and analyzed cell-free DNA sequencing data from 86 patients with mCRPC. In addition to frequent rearrangements affecting known prostate cancer genes, we observed...
Lymphomatous involvement of the gallbladder is extremely rare. We report on a 69-year-old woman with a history of an indolent non-Hodgkin’s lymphoma who was found to have a new gallbladder lesion on surveillance CT scan. The mass was resected and proved to be a follicular lymphoma with the same immunohistochemical characteristics as her original tumor 12 years prior.
Lin28, a highly conserved RNA-binding protein, has emerged as a modulator of the processing of the let-7 microRNA. This role for Lin28 has important implications for our mechanistic understanding of pluripotency, the timing of development, and oncogenesis.
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