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Dexamethasone (Dex, 0.1 mg/kg, s.c.) suppressions of ischemic paw edema in mice at 1, 3, 6, 8, 18 hr were: 2, 22, 12, 11, 7 %. Dex suppression in fructose-1,6-diphosphate (FDP, 100 mg/kg, i.p.)-treated mice were; 5, 49, 51, 42, 33 %. Suppressions by this dose of FDP alone were less than 10 % during 0 - 18 hr. ED 30 at 6 hr of Dex ± FDP was: 80 versus 500 mg/kg in ischemic-, and 5 versus...
Dexamethasone (0.1 mg/kg, s.c.) suppressed 2, 22, 12, 6, and 4% of ischemic paw edema of mice at 1,3, 6, 18, and 40 h. Various antioxidants when given with 0.1 mg/kg Dex enhanced and prolonged the suppression. For example, 30 mg/kg of tannic acid induced suppression of 6, 52, 59, 42 and 27%, whereas no increase of Dex suppression at 1 h was observed with any of the antioxidants tested. The prolonging...
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