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Rationale. In the absence of agonists and antagonists evidencing appropriate selectivities, individual and interactive properties of D1 and D3 dopamine receptors would be illuminated most powerfully by their co-deletion. Objectives. To define and contrast the behavioural phenotype of D1/D3 double knockout mice in comparison with wild types, and with individual D1 and D3 mutants. Methods. Behavioural...
The genetic basis of a number of epilepsy syndromes has been identified but the precise mechanism whereby these mutations produce seizures is unknown. Three mutations of the α 4 subunit of the neuronal nicotinic acetylcholine receptor (nAChR) have been identified in autosomal dominant nocturnal frontal lobe epilepsy. In vitro studies of two mutations suggest an alteration of receptor function...
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