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Asthma and chronic obstructive pulmonary disease (COPD) are characterized by airway obstruction, hyperresponsiveness and inflammation. The tachykinins substance P and neurokinin A are present in the human airways where they are found in sensory nerves and immune cells. Tachykinins are released in the airways after inhalation of ozone, cigarette smoke or allergen. They interact in the airways with...