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In Graves’ disease (GD) immunized T cells reactive to TSH-receptor epitopes contribute to pathogenesis through B cell help, and cytotoxicity. We evaluated T cell responses to synthetic TSH-receptor epitopes in hyperthyroid patients with GD prior to therapy, at 6–8 weeks after radioactive iodine (RAI) administration, or 6–8 months later when euthyroid, and in control subjects. All T cell responses...