Search results for: Carlos Polanco

Items from 1 to 20 out of 36 results

article

Exosomal and vesicle‐free tau seeds—propagation and convergence in endolysosomal permeabilization

Juan Carlos Polanco, Jürgen Götz

The FEBS Journal > 289 > 22 > 6891 - 6907

In Alzheimer's disease (AD), β‐amyloid peptides aggregate to form amyloid plaques, and the microtubule‐associated protein tau forms neurofibrillary tangles. However, severity and duration of AD correlate with the stereotypical emergence of tau tangles throughout the brain, suggestive of a gradual region‐to‐region spreading of pathological tau. The current notion in the field is that misfolded tau...

article

Non‐stochastic behavior in sodium chlorate crystallization

José‐Manuel Cruz, Karem Hernández‐Lechuga, Israel Domínguez‐Valle, Alejandro Fuentes‐Beltrán, more

Chirality > 32 > 1 > 120 - 134

NaClO₃ is achiral in solution. If crystallization is performed under a static set‐up, it is recognized that the stochastic nucleation probability results in a racemic mixture of the conglomerate. In this paper, we report a reexamination of the crystallization of NaClO₃ from static solution in petri dishes that was conducted over a number of years and is based on the count and analysis of several thousand...

article

Cost per response for abatacept versus adalimumab in patients with seropositive, erosive early rheumatoid arthritis in the US, Germany, Spain, and Canada

Jason Foo, Chaienna Morel, Martin Bergman, Christoph Baerwald, more

Rheumatology International > 2019 > 39 > 9 > 1621-1630

Background Effective treatment of rheumatoid arthritis (RA) with biologic DMARDs poses a significant economic burden. The AMPLE (Abatacept versus adaliMumab comParison in bioLogic-naïvE RA subjects with background methotrexate) trial was a head-to-head, randomized study comparing abatacept with adalimumab. A post hoc analysis showed improved efficacy for abatacept in patients with versus without seropositive,...

article

On the Regularities of the Polar Profiles of Proteins Related to Ebola Virus Infection and their Functional Domains

Carlos Polanco, José Lino Samaniego Mendoza, Thomas Buhse, Vladimir N. Uversky, more

Cell Biochemistry and Biophysics > 2018 > 76 > 3 > 411-431

The number of fatalities and economic losses caused by the Ebola virus infection across the planet culminated in the havoc that occurred between August and November 2014. However, little is known about the molecular protein profile of this devastating virus. This work represents a thorough bioinformatics analysis of the regularities of charge distribution (polar profiles) in two groups of proteins...

article

Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons

Juan Carlos Polanco, Chuanzhou Li, Nela Durisic, Robert Sullivan, more

Acta Neuropathologica Communications > 2018 > 6 > 1 > 1-14

In Alzheimer disease and related disorders, the microtubule-associated protein tau aggregates and forms cytoplasmic lesions that impair neuronal physiology at many levels. In addition to affecting the host neuron, tau aggregates also spread to neighboring, recipient cells where the misfolded tau aggregates, in a manner similar to prions, actively corrupt the proper folding of soluble tau, and thereby...

article

Analysis of somaclonal variation in transgenic and regenerated plants of Arabidopsis thaliana using methylation related metAFLP and TMD markers

Carlos J. Coronel, Ana I. González, María L. Ruiz, Carlos Polanco

Plant Cell Reports > 2018 > 37 > 1 > 137-152

Key message We provide evidence that nucleotide sequence and methylation status changes occur in the Arabidopsis genome during in vitro tissue culture at a frequency high enough to represent an important source of variation. Abstract Somaclonal variation is a general consequence of the tissue culture process that has to be analyzed specifically when regenerated plants are obtained in any plant species...

article

Electronegativity and intrinsic disorder of preeclampsia-related proteins

Carlos Polanco, Jorge Castañón-González, Vladimir Uversky, Thomas Buhse, more

Acta Biochimica Polonica > 2017 > 64 > 1 > 99-111

Preeclampsia, hemorrhage, and infection are the leading causes of maternal death in underdeveloped countries. Since several proteins associated with preeclampsia are known, we conducted a computational study which evaluated the commonness and potential functionality of intrinsic disorder of these proteins and also made an attempt to characterize their origin. The origin of the preeclampsia-related...

article

Non-racemic mixture model: a computational approach

Carlos Polanco, Thomas Buhse

Acta Biochimica Polonica > 2017 > 64 > 1 > 17-19

The behavior of a slight chiral bias in favor of l-amino acids over d-amino acids was studied in an evolutionary mathematical model generating mixed chiral peptide hexamers. The simulations aimed to reproduce a very generalized prebiotic scenario involving a specified couple of amino acid enantiomers and a possible asymmetric amplification through autocatalytic peptide self-replication while forming...

article

The polar profile of ancient proteins: a computational extrapolation from prebiotics to paleobiochemistry

Carlos Polanco, Thomas Buhse, Gloria Vizcaíno, Jacobo Picciotto

Acta Biochimica Polonica > 2017 > 64 > 1 > 117-122

This paper addresses the polar profile of ancient proteins using a comparative study of amino acids found in 25 000 000-year-old shells described in Abelson's work. We simulated the polar profile with a computer platform that represented an evolutionary computational toy model that mimicked the generation of small proteins starting from a pool of monomeric amino acids and that included several dynamic...

article

Structure and function relationships of proteins based on polar profile: a review

Carlos Polanco, Thomas Buhse, Vladimir Uversky

Acta Biochimica Polonica > 2016 > 63 > 2 > 229-233

Proteins in the post-genome era impose diverse research challenges, the main are the understanding of their structure-function mechanism, and the growing need for new pharmaceutical drugs, particularly antibiotics that help clinicians treat the ever- increasing number of Multidrug-Resistant Organisms (MDROs). Although, there is a wide range of mathematical-computational algorithms to satisfy the demand,...

article

Classifying lipoproteins based on their polar profiles

Carlos Polanco, Jorge Castañón-González, Thomas Buhse, Vladimir Uversky, more

Acta Biochimica Polonica > 2016 > 63 > 2 > 235-241

The lipoproteins are an important group of cargo proteins known for their unique capability to transport lipids. By applying the Polarity index algorithm, which has a metric that only considers the polar profile of the linear sequences of the lipoprotein group, we obtained an analytical and structural differentiation of all the lipoproteins found in UniProt Database. Also, the functional groups of...

article

Identification of antimicrobial peptides by using eigenvectors

Carlos Polanco

Acta Biochimica Polonica > 2016 > 63 > 3 > 483-491

Antibacterial peptides are subject to broad research due to their potential application and the benefit they can provide for a wide range of diseases. In this work, a mathematical-computational method, called the Polarity Vector Method, is introduced that has a high discriminative level (>70%) to identify peptides associated with Gram (-) bacteria, Gram (+) bacteria, cancer cells, fungi, insects,...

article

Cost-effectiveness analysis of universal screening for thyroid disease in pregnant women in Spain

Sergio Donnay Candil, José Antonio Balsa Barro, Julia Álvarez Hernández, Carlos Crespo Palomo, more

Endocrinologia y nutricion (English Edition) > 2015 > 62 > 7 > 322-330

To assess the cost-effectiveness of universal screening for thyroid disease in pregnant women in Spain as compared to high risk screening and no screening.A decision-analytic model comparing the incremental cost per quality-adjusted life year (QALY) of universal screening versus high risk screening and versus no screening was used for the pregnancy and postpartum period. Probabilities from randomized...

article

Tau aggregation and its interplay with amyloid-β

Rebecca M. Nisbet, Juan-Carlos Polanco, Lars M. Ittner, Jürgen Götz

Acta Neuropathologica > 2015 > 129 > 2 > 207-220

Neurofibrillary tangles and amyloid plaques constitute the hallmark brain lesions of Alzheimer’s disease (AD) patients. Tangles are composed of fibrillar aggregates of the microtubule-associated protein tau, and plaques comprise fibrillar forms of a proteolytic cleavage product, amyloid-β (Aβ). Although plaques and tangles are the end-stage lesions in AD, small oligomers of Aβ and tau are now receiving...

article

Identification of proteins associated with amyloidosis by polarity index method

Carlos Polanco, José Samaniego, Vladimir Uversky, Jorge Castañón-González, more

Acta Biochimica Polonica > 2015 > 62 > 1 > 41-55

There is a natural protein form, insoluble and resistant to proteolysis, adopted by many proteins independently of their amino acid sequences via specific misfolding-aggregation process. This dynamic process occurs in parallel with or as an alternative to physiologic folding, generating toxic protein aggregates that are deposited and accumulated in various organs and tissues. These proteinaceous deposits...

article

Identification of proteins associated with Mycobacterium tuberculosis virulence pathway by their polar profile

Carlos Polanco, Jorge Castañón-González, Raul Mancilla, Thomas Buhse, more

Acta Biochimica Polonica > 2015 > 62 > 2 > 191-196

With almost one third of the world population infected, tuberculosis is one of the most devastating diseases worldwide and it is a major threat to any healthcare system. With the mathematical-computational method named "Polarity Index Method", already published by this group, we identified, with high accuracy (70%), proteins related to Mycobacterium tuberculosis bacteria virulence pathway...

article

ANALYSIS OF TAU PROTEIN IN EXOSOMES AND MICROVESICLES ISOLATED FROM A MOUSE MODEL OF ALZHEIMER'S DISEASE

Juan Carlos Polanco, Benjamin James Scicluna, Andrew Francis Hill, Jürgen Götz

Alzheimer's & Dementia: The Journal of the Alzheimer's Association > 2014 > 10 > 4 Supplement > P649

article

Polar Characterization of Antifungal Peptides from APD2 Database

Carlos Polanco, José Lino Samaniego-Mendoza, Thomas Buhse, Jorge Alberto Castañón-González, more

Cell Biochemistry and Biophysics > 2014 > 70 > 2 > 1479-1488

The increase in the number of pathogens due to fungi that are tolerant to therapies does not grow at the same speed than the advance on new antifungal drugs. In this sense, it is imperative to find anti-fungi peptides that are not detrimental to mammalian cells and have an effective toxicity to fungi. In this work, we use a method called polarity index, to identify anti-fungi peptides with an efficiency...

article

Polar Profile of Antiviral Peptides from AVPpred Database

Carlos Polanco, José Lino Samaniego, Jorge Alberto Castañón-González, Thomas Buhse

Cell Biochemistry and Biophysics > 2014 > 70 > 2 > 1469-1477

Diseases of viral origin in humans are among the most serious threats to health and the global economy. As recent history has shown the virus has a high pandemic potential, among other reasons, due to its ability to spread by air, hence the identification, investigation, containment, and treatment of viral diseases should be considered of paramount importance. In this sense, the bioinformatics research...

article

Discrete dynamic system oriented on the formation of prebiotic dipeptides from Rode's experiment

Carlos Polanco, José Samaniego, Thomas Buhse, Jorge Castañón González

Acta Biochimica Polonica > 2014 > 61 > 4 > 717-726

This work attempts to rationalize the possible prebiotic profile of the first dipeptides of about 4 billion years ago based on a computational discrete dynamic system that uses the final yields of the dipeptides obtained in Rode's experiments of salt-induced peptide formation (Rode et al., 1999, Peptides 20: 773-786). The system built a prebiotic scenario that allowed us to observe that (i) the primordial...

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INFONA - science communication portal

Search results for: Carlos Polanco

Exosomal and vesicle‐free tau seeds—propagation and convergence in endolysosomal permeabilization

Non‐stochastic behavior in sodium chlorate crystallization

Cost per response for abatacept versus adalimumab in patients with seropositive, erosive early rheumatoid arthritis in the US, Germany, Spain, and Canada

On the Regularities of the Polar Profiles of Proteins Related to Ebola Virus Infection and their Functional Domains

Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons

Analysis of somaclonal variation in transgenic and regenerated plants of Arabidopsis thaliana using methylation related metAFLP and TMD markers

Electronegativity and intrinsic disorder of preeclampsia-related proteins

Non-racemic mixture model: a computational approach

The polar profile of ancient proteins: a computational extrapolation from prebiotics to paleobiochemistry

Structure and function relationships of proteins based on polar profile: a review

Classifying lipoproteins based on their polar profiles

Identification of antimicrobial peptides by using eigenvectors

Cost-effectiveness analysis of universal screening for thyroid disease in pregnant women in Spain

Tau aggregation and its interplay with amyloid-β

Identification of proteins associated with amyloidosis by polarity index method

Identification of proteins associated with Mycobacterium tuberculosis virulence pathway by their polar profile

ANALYSIS OF TAU PROTEIN IN EXOSOMES AND MICROVESICLES ISOLATED FROM A MOUSE MODEL OF ALZHEIMER'S DISEASE

Polar Characterization of Antifungal Peptides from APD2 Database

Polar Profile of Antiviral Peptides from AVPpred Database

Discrete dynamic system oriented on the formation of prebiotic dipeptides from Rode's experiment

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