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Technological developments in magnetic resonance imaging have provided the methods to non-invasively and repeatedly monitor cerebral blood flow (CBF) and water dynamics in human and experimental animals [1, 2]. Cerebral ischemia is associated with brain edema and tissue injury but the correlation between transient reductions in CBF and alterations in brain water are not well understood [3]. We determined...
A transient episode of cerebral hypoxia-ischemia will produce transient biochemical and cellular changes that may be followed by a delayed cell death. Magnetic resonance (MR) imaging techniques have demonstrated that despite a normalization of images post reperfusion, a secondary or delayed return of hyperintense areas in the T2 and diffusion weighted (DW) images can appear several hours after the...
AbstractThe present study examines the effect of dexamethasone treatment on the intensity of changes in T2-weighted and diffusion-weighted (DW) magnetic resonance images occurring in infant rats during and after cerebral hypoxia-ischemia. The right carotid artery was occluded under isoflurane anesthesia in 7-day-old rats and images were acquired in sedated animals using a Bruker 9.4 T magnetic resonance...
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