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Insulin-like growth factor 2 receptor (IGF2R) is responsible for degradation of the muscle development initiator, IGF2, and thus it can be used as a marker for selection strategies in the farm animals. The aim of this study was to search for polymorphisms in three coding loci of IGF2R, and to analyze their effect on the growth traits and on the expression levels of IGF2R and IGF2 genes in the gluteus...
The combination of the KitW mutation and KitS allele from Mus spretus leads to male hybrid sterility. The effects of other combinations between KitW and KitM from Mus m. molossinus or KitN from Mus m. musculus on male reproductive ability were examined in this study. The KitW/KitM and KitW/KitN males were fertile and showed the normal pattern of spermatogenesis in most seminiferous tubules...
Two congenic strains, C57BL-KitW and C57BL-KitS, were generated. The KitW allele originated from strain WB-KitW and the KitS allele from Mus spretus. The KitW/KitS males showed hybrid sterility with small testes, but the females were fertile. The development of the seminiferous tubules of KitW/KitS males stopped before the spermatocyte stage and they were almost free of sperm. The Kit gene is located...
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