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Membrane lipid regulation of cell function is poorly understood. In early development, sterol efflux and the ganglioside G M1 regulate sperm acrosome exocytosis (AE) and fertilization competence through unknown mechanisms. Here, we show that sterol efflux and focal enrichment of G M1 trigger Ca 2+ influx necessary for AE through Ca V 2.3, whose activity has been highly...
The One Health concept promotes collaboration among veterinarians, physicians, scientists, and other professions to promote human, animal, and ecosystem health. One Health illustrates the interconnectedness and interdependence of human, animal, and ecosystem health. This concept has traditionally focused on zoonoses that are infectious diseases, not on chemical- or poison-related illnesses in animals...
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