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Background and Objectives Genetic studies have revealed that the regulated upon activation normal T-cell expressed and secreted (RANTES) −28C/G and −403G/A polymorphisms are associated with asthma risk, but contradictory findings have also been reported. Therefore, we undertook a meta-analysis on this topic. Methods The PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and...
Data on the association between the ghrelin Leu72Met polymorphism and type 2 diabetes are conflicting. A meta-analysis was performed on this topic.We searched for case–control studies using electronic databases (Medline and PubMed) and reference lists of studies. Odds ratios (OR) and 95% confidence intervals (CI) assuming dominant, recessive and homozygote comparison genetic models were calculated...
Background Dysregulated levels of interleukin-1 (IL-1) were observed in patients with multiple sclerosis (MS). Previous studies have provided conflicting evidence implicating the IL-1 gene polymorphisms in MS risk. Methods A meta-analysis of 16 case–control studies involving 3,482 cases and 3,528 controls was conducted to evaluate this association. Results No association was found between the...
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