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This chapter discusses the normal structure and function of the skeleton and the various ways it is regulated. The skeleton is both an organ and a type of connective tissue. Knowledge of its various identifiable parts greatly facilitates an understanding of skeletal function and also the disease processes that can occur. Normally, the major skeletal processes of resorption and formation are tightly...
The laboratory in orthopedic practice is involved in a variety of ways. These include the tissue bank that helps with the storage and retrieval of nucleic acids. The molecular and cytogenetic laboratory is also involved in their analysis and molecular genetic studies for tumors and skeletal diseases and dysplasias. The anatomic pathology laboratory is of course involved in the analysis of biopsy and...
The chapter discusses bone metabolism and regulation under normal conditions. It also discusses disease conditions that affect the skeleton as a whole including osteo-porosis, rickets, osteomalacia, scurvy, renal osteodystrophy, hyperparthyroidism, storage disorders and amyloidosis. Paget disease is also discussed here because of tradition and its similarity to other generalized skeletal disorders...
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