Search results for: P Stefan Biesbroek

Items from 1 to 11 out of 11 results

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Myocardial adaptation after surgical therapy differs for aortic valve stenosis and hypertrophic obstructive cardiomyopathy

Rahana Y. Parbhudayal, Ahmet Güçlü, Alwin Zweerink, P. Stefan Biesbroek, more

The International Journal of Cardiovascular Imaging > 2019 > 35 > 6 > 1089-1100

Surgical therapies in aortic valve stenosis (AVS) and hypertrophic obstructive cardiomyopathy (HOCM) aim to relief intraventricular pressure overload and improve clinical outcome. It is currently unknown to what extent myocardial adaptation concurs with restoration of intraventricular pressures, and whether this is similar in both patient groups. The aim of this study was to investigate changes in...

article

Assessment of aortic stiffness in patients with ankylosing spondylitis using cardiovascular magnetic resonance

P. Stefan Biesbroek, Sjoerd C. Heslinga, Peter M. Ven, Mike J. L. Peters, more

Clinical Rheumatology > 2018 > 37 > 8 > 2151-2159

To evaluate aortic stiffness in patients with ankylosing spondylitis (AS) using cardiovascular magnetic resonance (CMR) and to assess its association with AS characteristics and left ventricular (LV) remodeling. In this prospective study, 14 consecutive AS patients were each matched to two controls without cardiovascular symptoms or known cardiovascular disease who underwent CMR imaging for the assessment...

article

The influence of microvascular injury on native T1 and T2* relaxation values after acute myocardial infarction: implications for non-contrast-enhanced infarct assessment

Lourens F. H. J. Robbers, Robin Nijveldt, Aernout M. Beek, Paul F. A. Teunissen, more

European Radiology > 2018 > 28 > 2 > 824-832

Objectives Native T1 mapping and late gadolinium enhancement (LGE) imaging offer detailed characterisation of the myocardium after acute myocardial infarction (AMI). We evaluated the effects of microvascular injury (MVI) and intramyocardial haemorrhage on local T1 and T2* values in patients with a reperfused AMI. Methods Forty-three patients after reperfused AMI underwent cardiovascular magnetic...

article

Usefulness of Left Atrial Emptying Fraction to Predict Ventricular Arrhythmias in Patients With Implantable Cardioverter Defibrillators

Mischa T. Rijnierse, Mehran Kamali Sadeghian, Sophie Schuurmans Stekhoven, P. Stefan Biesbroek, more

The American Journal of Cardiology > 2017 > 120 > 2 > 243-250

Impaired left atrial emptying fraction (LAEF) is an important predictor of mortality in patients with heart failure. As it may reflect increased LV wall stress, it might predict ventricular arrhythmia (VA) specifically. This study evaluated the predictive value of LAEF assessed with cardiovascular magnetic resonance (CMR) imaging with respect to appropriate device therapy (ADT) for VA and compared...

article

Lymphocytic myocarditis occurs with myocardial infarction and coincides with increased inflammation, hemorrhage and instability in coronary artery atherosclerotic plaques

Linde Woudstra, P. Stefan Biesbroek, Reindert W. Emmens, Stephane Heymans, more

International Journal of Cardiology > 2017 > 232 > C > 53-62

Although lymphocytic myocarditis (LM) clinically can mimic myocardial infarction (MI), they are regarded as distinct clinical entities. However, we observed a high prevalence (32%) of recent MI in patients diagnosed post-mortem with LM. To investigate if LM changes coronary atherosclerotic plaque, we analyzed in autopsied hearts the inflammatory infiltrate and stability in coronary atherosclerotic...

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CD45 is a more sensitive marker than CD3 to diagnose lymphocytic myocarditis in the endomyocardium

Linde Woudstra, P. Stefan Biesbroek, Reindert W. Emmens, Stephane Heymans, more

Human Pathology > 2017 > 62 > C > 83-90

To diagnose lymphocytic myocarditis (LM), immunohistopathological examination of endomyocardial biopsies (EMBs) is used with a cutoff value of at least 14 leukocytes per mm², composed of CD3- and CD68-positive cells. We hypothesized that a more common leukocyte marker, CD45, instead of CD3 could increase the diagnostic sensitivity. Hearts of mice with acute viral myocarditis (n = 9) and of controls...

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Reversed takotsubo cardiomyopathy in a patient with new-onset multiple sclerosis: Cause, link, or just coincidence?

P. Stefan Biesbroek, Robin Nijveldt, Brigit A. de Jong, Albert C. van Rossum, more

International Journal of Cardiology > 2016 > 207 > C > 217-219

article

Ventricular myocarditis coincides with atrial myocarditis in patients

Mark P.V. Begieneman, Reindert W. Emmens, Liza Rijvers, Bela Kubat, more

Cardiovascular Pathology > 2016 > 25 > 2 > 141-148

Atrial fibrillation (AF) is a common complication in myocarditis. Atrial inflammation has been suggested to play an important role in the pathophysiology of AF. However, little is known about the occurrence of atrial inflammation in myocarditis patients. Here, we analyzed inflammatory cell numbers in the atria of myocarditis patients without symptomatic AF.Cardiac tissue was obtained postmortem from...

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Fluoroscopy Assisted Scoring of Myocardial Hypoperfusion (FLASH) ratio as a novel predictor of mortality after primary PCI in STEMI patients

P. Stefan Biesbroek, Sebastiaan T. Roos, Max van Hout, Jack van der Gragt, more

International Journal of Cardiology > 2016 > 202 > C > 639-645

The aim of this study was to investigate whether Fluoroscopy Assisted Scoring of Myocardial Hypoperfusion (FLASH) enabled a more accurate assessment of coronary blood flow and prediction of cardiac mortality after primary PCI (pPCI), than the presently used angiographic scores of reperfusion.We included 453 STEMI patients who received pPCI at our hospital. Using the novel FLASH algorithm, based on...

article

Diagnosis of myocarditis: Current state and future perspectives

P. Stefan Biesbroek, Aernout M. Beek, Tjeerd Germans, Hans W.M. Niessen, more

International Journal of Cardiology > 2015 > 191 > Complete > 211-219

Myocarditis, i.e. inflammation of the myocardium, is one of the leading causes of sudden cardiac death (SCD) and dilated cardiomyopathy (DCM) in young adults, and is an important cause of symptoms such as chest pain, dyspnea and palpitations. The pathophysiological process of disease progression leading to DCM involves an ongoing inflammation as a result of a viral-induced auto-immune response or...

article

The value of cardiac magnetic resonance in the prediction of left ventricular function improvement following acute myocarditis

P Stefan Biesbroek, Esha Kumar, Aernout M Beek, Albert C van Rossum

Journal of Cardiovascular Magnetic Resonance > 2015 > 17 > 1 > 1-1

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