Search results for: Irene Brunk

Items from 1 to 12 out of 12 results

article

Profiling learning strategies of medical students: A person‐centered approach

Nils Otto, Anja Böckers, Thomas Shiozawa, Irene Brunk, more

Medical Education > 58 > 11 > 1304 - 1314

Background Students within a cohort might employ unique subsets of learning strategies (LS) to study. However, little research has aimed to elucidate subgroup‐specific LS usage among medical students. Recent methodological developments, particularly person‐centred approaches such as latent profile analysis (LPA), offer ways to identify relevant subgroups with dissimilar patterns of LS use. In this...

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Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system

Jens Baron, Ainhoa Bilbao, Heide Hörtnagl, Lutz Birnbaumer, more

Journal of Neurochemistry > 146 > 4 > 374 - 389

The heterotrimeric G‐protein Go with its splice variants, Go1α and Go2α, seems to be involved in the regulation of motor function but isoform‐specific effects are still unclear. We found that Go1α‐/‐ knockouts performed worse on the rota‐rod than Go2α‐/‐ and wild‐type (WT) mice. In Go1+2α‐/‐ mice motor function was partially recovered. Furthermore, Go1+2α‐/‐ mice showed an increased spontaneous motor...

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Do they know too little? An inter-institutional study on the anatomical knowledge of upper-year medical students based on multiple choice questions of a progress test

Irene Brunk, Stefan Schauber, Waltraud Georg

Annals of Anatomy - Anatomischer Anzeiger > 2017 > 209 > C > 93-100

The depth of medical students’ knowledge of human anatomy is often controversially discussed. In particular, members of surgical disciplines raise concerns regarding deficits in the factual anatomical and topographical knowledge of upper-year students. The question often raised is whether or not medical students have sufficient anatomical and topographical knowledge when they graduate from medical...

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The α‐subunit of the trimeric GTPase Go2 regulates axonal growth

Jens Baron, Christian Blex, Astrid Rohrbeck, Sivarama Krishna Rachakonda, more

Journal of Neurochemistry > 124 > 6 > 782 - 794

The Goα splice variants Go1α and Go2α are subunits of the most abundant G‐proteins in brain, Go1 and Go2. Only a few interacting partners binding to Go1α have been described so far and splice variant‐specific differences are not known. Using a yeast two‐hybrid screen with constitutively active Go2α as bait, we identified Rap1GTPase activating protein (Rap1GAP) and Girdin as interacting partners of...

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Synaptic PRG-1 Modulates Excitatory Transmission via Lipid Phosphate-Mediated Signaling

Thorsten Trimbuch, Prateep Beed, Johannes Vogt, Sebastian Schuchmann, more

Cell > 2011 > 146 > 6 > 1043

article

Neurotoxic phospholipases directly affect synaptic vesicle function

Philipp Treppmann, Irene Brunk, Terence Afube, Karin Richter, more

Journal of Neurochemistry > 117 > 4 > 757 - 764

J. Neurochem. (2011) 117, 757–764. AbstractSnake neurotoxic phospholipases (SPAN) exclusively affect pre‐synaptic nerve terminals where they lead to a block of neurotransmission by not fully understood mechanisms. Here, we report that the SPANs, taipoxin and paradoxin, in nanomolar concentrations directly dissociate the synaptophysin/synaptobrevin (Syp/Syb) complex on isolated synaptic vesicles in...

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Amphetamine regulates NR2B expression in Go2α knockout mice and thereby sustains behavioral sensitization

Irene Brunk, Carles Sanchis‐Segura, Christian Blex, Stéphanie Perreau‐Lenz, more

Journal of Neurochemistry > 115 > 1 > 234 - 246

J. Neurochem. (2010) 115, 234–246. AbstractThe α‐subunit of Go2 is a regulator of dopamine (DA) homeostasis. Deletion of the protein results in an imbalance of the direct and indirect DA pathway by reducing D1 and increasing D2 receptors. As a result, cocaine‐induced behavioral sensitization is abolished. Here we show that repeated amphetamine injections in Go2α−/− mice induced a similar D1/D2 receptor...

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Age-dependent axonal expression of potassium channel proteins during development in mouse hippocampus

Harald Prüss, Gisela Grosse, Irene Brunk, Rüdiger W. Veh, more

Histochemistry and Cell Biology > 2010 > 133 > 3 > 301-312

The development of the hippocampal network requires neuronal activity, which is shaped by the differential expression and sorting of a variety of potassium channels. Parallel to their maturation, hippocampal neurons undergo a distinct development of their ion channel profile. The age-dependent dimension of ion channel occurrence is of utmost importance as it is interdependently linked to network formation...

article

Synaptic PRG-1 Modulates Excitatory Transmission via Lipid Phosphate-Mediated Signaling

Thorsten Trimbuch, Prateep Beed, Johannes Vogt, Sebastian Schuchmann, more

Cell > 2009 > 138 > 6 > 1222-1235

Plasticity related gene-1 (PRG-1) is a brain-specific membrane protein related to lipid phosphate phosphatases, which acts in the hippocampus specifically at the excitatory synapse terminating on glutamatergic neurons. Deletion of prg-1 in mice leads to epileptic seizures and augmentation of EPSCs, but not IPSCs. In utero electroporation of PRG-1 into deficient animals revealed that PRG-1 modulates...

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Regulation of Monoamine Oxidase A by Circadian-Clock Components Implies Clock Influence on Mood

Gabriele Hampp, Jürgen A. Ripperger, Thijs Houben, Isabelle Schmutz, more

Current Biology > 2008 > 18 > 9 > 678-683

The circadian clock has been implicated in addiction and several forms of depression [1, 2], indicating interactions between the circadian and the reward systems in the brain [3–5]. Rewards such as food, sex, and drugs influence this system in part by modulating dopamine neurotransmission in the mesolimbic dopamine reward circuit, including the ventral tegmental area (VTA) and the ventral striatum...

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Ehlers-Danlos syndrome type VI with cystic malformations of the meninges in a 7-year-old girl

Irene Brunk, Brigitte Stver, Chrysanthy Ikonomidou, Jrgen Brinckmann, more

European Journal of Pediatrics > 2004 > 163 > 4-5 > 214-217

A 7-year-old girl with thoracolumbar kyphoscoliosis was admitted for further diagnostic evaluation after a spinal MRI scan had shown several intraspinal extramedullary lesions. The clinical features including joint hypermobility and cigarette-paper like scars led to the presumptive diagnosis of Ehlers-Danlos syndrome type VI (EDS VI). Analysis of urinary lysyl- and hydroxylysyl-pyridinoline cross-links...

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Differential distribution of G-protein β-subunits in brain: An immunocytochemical analysis

Irene Brunk, Ingrid Pahner, Udo Maier, Bernd Jenner, more

European Journal of Cell Biology > 1999 > 78 > 5 > 311-322

Heterotrimeric G proteins play central roles in signal transduction of neurons and other cells. The variety of their α-, β-, and γ-subunits allows numerous combinations thereby confering specificity to receptor-G-protein-effector interactions. Using antisera against individual G-protein α-subunits we here present a regional and subcellular distribution of Gβ ₁ , Gβ ₂ , and Gβ ₅...

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