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According to the constant senescence hypothesis, senescence cannot be accelerated or decelerated by exogenous factors. Two contrasting theories have been proposed in the literature. According to the inflammaging theory, those individuals who have experienced a higher antigenic load will experience more rapid senescence. Instead, the calorie restriction theory stresses that excessive daily calorie...
Physiological senescence is characterized by the increasing limitation of capabilities of an organism resulting from the progressive accumulation of molecular damage, which at group (cohort) level translates into, among other things, an increase in mortality risks with age. Physiological senescence is generally thought to begin at birth, if not earlier, but models of demographic aging (i.e., an increase...
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