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Purpose: Our previous studies showed that tumor necrosis factor (TNF)- and interleukin (IL)-6 are induced after hemorrhagic shock and that their induction is attenuated by hyperbaric oxygen treatment. In this study, we tried to identify the cell types in the liver that are responsible for the increase in TNF- mRNA and IL-6 mRNA after hemorrhage using in situ reverse transcriptionpolymerase chain reaction...
Treatment with endotoxin leads to a rise in plasminogen activator inhibitor-1 (PAI-1) both in vivo and in vitro. Although a recent study insists that inhibition of tumor necrosis factor alpha (TNFα) does not reduce the induction of PAI-1 by endotoxin in rats, we imagine that TNFα is involved in the induction of PAI-1 by endotoxin, because endotoxin treatment induces TNFα and administration of TNFα...
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