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Lymph node metastasis represents the first step of spread for most human cancers and serves as an important prognostic indicator. Recent studies have revealed that tumors can actively induce the growth of tumor-associated lymphatic vessels (lymphangiogenesis), thus promoting their metastasis to draining (sentinel) lymph nodes. Several tumor lymphangiogenesis factors have been identified, including...
Tumor lymphangiogenesis promotes metastatic cancer spread to lymph nodes and beyond. However, the potential remodeling and functionality of tumor-draining lymphatic vessels has remained unclear. Thus, we aimed to develop non-invasive imaging methods for repeated quantitative imaging of lymphatic drainage and of contractile collecting lymphatic vessel function in mice, with colloidal near-infrared...
Microencapsulation of desired mammalian cell phenotypes in biocompatible polymer matrices represents a powerful technology for cell-based therapies and biopharmaceutical manufacturing of protein therapeutics. We have pioneered a novel jet break-up-compatible process for encapsulation of mammalian cells in cellulose sulfate (CS)/poly-diallyl-dimethyl-ammoniumchloride (pDADMAC) (CellMAC) capsules. CS...
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