P. D’Amelio

article

Gut Microbiota, Immune System, and Bone

P. D’Amelio, F. Sassi

Calcified Tissue International > 2018 > 102 > 4 > 415-425

The gut microbiota (GM) is the whole of commensal, symbiotic, and pathogenic microorganisms living in our intestine. The GM–host interactions contribute to the maturation of the host immune system, modulating its systemic response. It is well documented that GM can interact with non-enteral cells such as immune cells, dendritic cells, and hepatocytes, producing molecules such as short-chain fatty...

chapter

Convective Thermal Field Reconstruction by Ordinary Kriging in Karstic Aquifers (Puglia, Italy): Geostatistical Analysis of Anisotropy

M. D. Fidelibus, L. Tulipano, P. D’Amelio

Environmental Earth Sciences > Advances in Research in Karst Media > Karst Hydrogeology > 203-208

The flow system in fractured aquifers is complex to define. A reliable outline of flow system in such a type of aquifers can be obtained by using natural tracers: among them, temperature demonstrates very effective usuage. Convective thermal fields, resulting from convective disturbance on conductive thermal fields, can be reasonably interpreted like analogues of flow systems. A geostatistical approach...

article

Treatment with intermittent PTH increases Wnt10b production by T cells in osteoporotic patients

P. D’Amelio, F. Sassi, I. Buondonno, G. Fornelli, more

Osteoporosis International > 2015 > 26 > 12 > 2785-2791

Summary We evaluated the effect of parathyroid hormone (PTH) on Wnt10b production by immune system cells in humans. We showed that bone anabolic effect of intermittent PTH treatment may be amplified by T cells through increased production of Wnt10b. Chronic increase in PTH as in primary hyperparathyroidism does not increase Wnt10b expression. Introduction The aim of this study is to assess the effect...

article

Improving adherence to and persistence with oral therapy of osteoporosis

M. L. Bianchi, P. Duca, S. Vai, G. Guglielmi, more

Osteoporosis International > 2015 > 26 > 5 > 1629-1638

Summary Osteoporosis treatment has low adherence and persistence. This study evaluated if greater patient involvement could improve them. At 12 months, only 114 out of 344 participants were “fully adherent and persistent” (all drug doses taken throughout the study). Only frequency of drug administration had a significant influence on adherence. Introduction Osteoporosis affects millions...

article

Teriparatide increases the maturation of circulating osteoblast precursors

P. D’Amelio, C. Tamone, F. Sassi, L. D’Amico, more

Osteoporosis International > 2012 > 23 > 4 > 1245-1253

Summary This study shows that teriparatide promotes the circulating osteoblast (OB) precursor degree of maturation in patients affected by postmenopausal osteoporosis. Introduction Anabolic treatment with teriparatide has proven effective for the therapy of postmenopausal osteoporosis and significantly reduces the risk of non-vertebral fragility fractures. The aim of this study was to investigate...

article

Bone and bone marrow pro-osteoclastogenic cytokines are up-regulated in osteoporosis fragility fractures

P. D’Amelio, I. Roato, L. D’Amico, L. Veneziano, more

Osteoporosis International > 2011 > 22 > 11 > 2869-2877

Summary This study evaluates cytokines production in bone and bone marrow of patients with an osteoporotic fracture or with osteoarthritis by real time PCR, Western blot and immunohistochemistry. We demonstrate that the cytokine pattern is shifted towards osteoclast activation and osteoblast inhibition in patients with osteoporotic fractures. Introduction Fragility fractures are the resultant of...

article

Clinical characteristics and incidence of first fracture in a consecutive sample of post-menopausal women attending osteoporosis centers: The PROTEO-1 study

G. C. Isaia, V. Braga, S. Minisola, G. Bianchi, more

Journal of Endocrinological Investigation > 2011 > 34 > 7 > 534-540

Background: Osteoporosis is a highly prevalent disease and fractures are a major cause of disability and morbidity. Aim: The purpose of this study was to characterize post-menopausal women attending osteoporosis centers in Italy, to evaluate physician management, and to determine the incidence of first osteoporotic fracture. Subjects and methods: PROTEO-1 was an observational longitudinal...

article

Alendronate reduces osteoclast precursors in osteoporosis

P. D’Amelio, A. Grimaldi, M. A. Cristofaro, M. Ravazzoli, more

Osteoporosis International > 2010 > 21 > 10 > 1741-1750

Summary This study evaluates the effect of alendronate on osteoclastogenesis, cytokine production, and bone resorption in postmenopausal women. We suggest that it acts on mature bone resorbing osteoclasts after 3 months of treatment, whereas, after 1 year, it diminishes their formation by reducing their precursors and serum RANKL. Introduction Osteoclasts are the target cells of bisphosphonates,...

article

Hypovitaminosis D in Internal Medicine Inpatients

A. Corino, P. D’Amelio, R. Gancia, P. Rizzo, more

Calcified Tissue International > 2007 > 80 > 2 > 76-80

Some studies have suggested that hypovitaminosis D may be a consequence of protein-calorie malnutrition. This study assessed both the relationship between vitamin D status, malnutrition, calcium and phosphorus metabolism indices and the importance attached by internists to these alterations. There were 239 patients admitted to an internal medicine division who underwent examinations to assess nutritional...

article

Effects of Lifestyle and Risk Factors on Bone Mineral Density in a Cohort of Italian Women: Suggestion for a New Decision Rule

P. D’Amelio, C. Tamone, F. Pluviano, M. Di Stefano, more

Calcified Tissue International > 2005 > 77 > 2 > 72-78

In this study the authors analyzed the role of risk factors in postmenopausal osteoporosis in a cohort of Italian women and evaluated predictive values of decision rules for early identification of osteoporotic women. Furthermore, the authors investigated the prevalence of secondary osteoporosis in this population. Women who underwent bone densitometry were asked to answer a questionnaire about the...

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Search results for: P. D’Amelio

Gut Microbiota, Immune System, and Bone

Convective Thermal Field Reconstruction by Ordinary Kriging in Karstic Aquifers (Puglia, Italy): Geostatistical Analysis of Anisotropy

Treatment with intermittent PTH increases Wnt10b production by T cells in osteoporotic patients

Improving adherence to and persistence with oral therapy of osteoporosis

Teriparatide increases the maturation of circulating osteoblast precursors

Bone and bone marrow pro-osteoclastogenic cytokines are up-regulated in osteoporosis fragility fractures

Clinical characteristics and incidence of first fracture in a consecutive sample of post-menopausal women attending osteoporosis centers: The PROTEO-1 study

Alendronate reduces osteoclast precursors in osteoporosis

Hypovitaminosis D in Internal Medicine Inpatients

Effects of Lifestyle and Risk Factors on Bone Mineral Density in a Cohort of Italian Women: Suggestion for a New Decision Rule

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