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Foxp3 + T cells play a critical role for the maintenance of immune tolerance. Here we show that in mice, Foxp3 + T cells contributed to diversification of gut microbiota, particularly of species belonging to Firmicutes. The control of indigenous bacteria by Foxp3 + T cells involved regulatory functions both outside and inside germinal centers (GCs), consisting of suppression...
Abstract. The effects of glucagon and insulin on glucose production were explored directly using the isolated perfused liver of the Goto-Kakizaki (GK) rat, an animal model of type-2 diabetes. In the perfused liver of control rats, infusion of glucagon (0.061.0nM) into the portal vein dose-dependently increased glucose output. In the GK rat liver, in which the intracellular distribution of glycogen...
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