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Tamoxifen has been the mainstay of endocrine therapy for estrogen receptor-positive breast cancer. However, approximately 40% of breast cancer patients do not respond to tamoxifen treatment. Further, most tumors eventually acquire tamoxifen resistance. Therefore, it is necessary to develop effective modalities to enhance the efficacy of tamoxifen in breast cancer treatment. In this study, we investigated...
There have been no target molecules that have enabled us to diagnose lung cancer with high sensitivity and specificity even in its early clinical stages. A molecule termed novel oncogene with kinase-domain (NOK) was recently reported as a receptor protein tyrosine kinase that is expressed in some cancer cell lines and causes the transformation and progressive proliferation of normal cells. Therefore,...
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