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Key Points Excessive alcohol consumption contributes to 4 of the 10 leading causes of death in the United States. Alcohol consumption is split, with 33% of the population consuming 95% of the alcoholic beverages and 33% abstaining. The US population median intake is much less than the average (mean) intake. An increase in average alcohol intake could increase the harm to the...
Ecology develops awareness of dynamic interacting parts (whether enzymes and substrates, consumers and autotrophs, or predators and prey) which transfer energy, biomass, and information along chains of cause-and-effect connected events. This review will focus on polyunsaturated lipids that act in sequential steps that link cause to consequence, including some of the crosslinks that weave the chains...
Large population studies show that polyunsaturated fatty acids are important for human health, but determining relationships between the health benefits and the fatty acid content has been hampered by the unavailability of labor-effective high-throughput technologies. An automated high throughput fatty acid analysis was developed from a previous procedure based on direct transesterification including...
Clinical intervention trials and animal studies indicate that increasing dietary intakes of long chain n−3 FA or reducing linoleic acid intake may reduce aggressive and violent behaviors. Here we examine if economic measures of greater n−6 consumption across time and countries correlate with greater risk of homicide. Linoleic acid available for human consumption was calculated from World Health Organization...
The 2002 ISSFAL Meeting arranged a special evening discussion with professional dietitians about diet-tissue-disease relationships involving essential fatty acids and eicosanoids. The balance of eicosanoid precursors in human tissues differs widely, reflecting voluntary dietary choices among different groups worldwide. An empirical quantitative diet-tissue relationship fits these diverse values as...
The level of blood or brain alcohol is considered to influence alcohol ingestion by causing subjective perceptions or neural activations that are reinforcing or rewarding. Alcohol-dependent people may try to maintain some desired tissue level, drinking to replace the millimolar levels that were cleared from the blood by metabolism. The biomedical literature describes many approaches to understanding...
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