Search results for: Sridhar Muthusami

Items from 1 to 9 out of 9 results

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Cissus quadrangularis prevented the ovariectomy induced oxidative stress in the femur of adult albino rats

Sridhar Muthusami, Vasudevan Gopalakrishnan, Jone A. Stanley, Senthilkumar Krishnamoorthy, more

Biomedicine & Pharmacotherapy > 2016 > 81 > C > 416-423

The increasing evidence suggesting the role of free radicals in bone resorption and bone loss prompted us to explore whether the consumption of antioxidant rich medicinal plant C. quadrangularis modifies antioxidant status in ovariectomized rats.Twenty four female adult rats, 90days old showing regular estrous cycles were used for the present study. The animals were divided into two groups. The Group-1...

article

Cordycepin increases radiosensitivity in cervical cancer cells by overriding or prolonging radiation-induced G2/M arrest

Da Bin Seong, Semie Hong, Sridhar Muthusami, Won-Dong Kim, more

European Journal of Pharmacology > 2016 > 771 > C > 77-83

Cordycepin (3-deoxyadenosine) has many pharmacological activities. We studied the radiosensitising effect of cordycepin and the underlying mechanisms relating to cell cycle changes in two human uterine cervical cancer cell lines, ME180 and HeLa cells. Cordycepin produced concentration- and time-dependent reductions in cell viability with more pronounced effects in ME180 cells. Cells pre-treated with...

article

FTS is responsible for radiation-induced nuclear phosphorylation of EGFR and repair of DNA damage in cervical cancer cells

Sridhar Muthusami, D. S. Prabakaran, Jae-Ran Yu, Woo-Yoon Park

Journal of Cancer Research and Clinical Oncology > 2015 > 141 > 2 > 203-210

Purpose Radiation-induced nuclear stabilization and phosphorylation of epidermal growth factor receptor (EGFR) confers radioresistance. Understanding of the factor(s) regulating the nuclear stabilization and phosphorylation of EGFR is important for the modulation of radioresistance. Present study was designed to delineate the regulation of EGFR nuclear stabilization and phosphorylation by fused toes...

article

EGF-induced expression of Fused Toes Homolog (FTS) facilitates epithelial–mesenchymal transition and promotes cell migration in ME180 cervical cancer cells

Sridhar Muthusami, D.S. Prabakaran, Jae-Ran Yu, Woo-Yoon Park

Cancer Letters > 2014 > 351 > 2 > 252-259

The role of Fused Toes Homolog (FTS) in epidermal growth factor (EGF) induced epithelial–mesenchymal transition (EMT) in cervical cancer cells was studied. EGF treatment induced the change of EMT markers and increased cell migration. EGF treatment also increased phosphorylated EGFR and ERK and nuclear level of ATF-2. The binding of ATF-2 to the promoter region of FTS was evidenced after EGF treatment...

article

EGCG suppresses Fused Toes Homolog protein through p53 in cervical cancer cells

Sridhar Muthusami, D. S. Prabakaran, Zhengzhe An, Jae-Ran Yu, more

Molecular Biology Reports > 2013 > 40 > 10 > 5587-5596

The anticarcinogenic actions of epigallocatechin-3-gallate (EGCG), one of the main ingredients of green tea, against various cancer types including cervical cancer are well documented. Studies pertaining to the exact molecular mechanism by which EGCG induces cancer cell growth inhibition needs to be investigated extensively. In the present study, we observed a stupendous dose dependent reduction in...

article

Cissus quadrangularis augments IGF system components in human osteoblast like SaOS-2 cells

Sridhar Muthusami, Ilangovan Ramachandran, Senthilkumar Krishnamoorthy, Ramajayam Govindan, more

Growth Hormone & IGF Research > 2011 > 21 > 6 > 343-348

Osteoporosis is a public health problem which is associated with significant morbidity and mortality. Growth factors are produced locally in the bone and control cellular events such as induction of bone growth. Signaling through the Insulin-like growth factor (IGF)-I receptor (IGF-IR) by locally synthesized IGF - I or IGF-II in osteoblast is considered crucial for normal development and for bone...

article

Effects of Cissus quadrangularis on the proliferation, differentiation and matrix mineralization of human osteoblast like SaOS‐2 cells

Sridhar Muthusami, Krishnamoorthy Senthilkumar, Chandragandan Vignesh, Ramachandran Ilangovan, more

Journal of Cellular Biochemistry > 112 > 4 > 1035 - 1045

Osteoporosis is a public health problem which is associated with significant morbidity and mortality. The repair of bone defect is still a big challenge for orthopedic surgeons. Traditional use of Cissus quadrangularis (C. quadrangularis) in the treatment of bone disorders has been documented. The present study was employed to delineate the effects of ethanolic extract of C. quadrangularis on the...

article

Effect of melatonin on PCB (Aroclor 1254) induced neuronal damage and changes in Cu/Zn superoxide dismutase and glutathione peroxidase-4 mRNA expression in cerebral cortex, cerebellum and hippocampus of adult rats

Prabhu Venkataraman, Kandaswamy Selvakumar, Gunasekaran Krishnamoorthy, Sridhar Muthusami, more

Neuroscience Research > 2010 > 66 > 2 > 189-197

Polychlorinated biphenyls (PCBs) are one of the environmental toxicants and neurotoxic compounds which induce the production of free radicals leading to oxidative stress. Free radicals represent a class of biologically generated species that pose a potential threat to neuronal survival. Cu/Zn superoxide dismutase (SOD) and glutathione peroxidase-4 (GPx-4) are the key cellular antioxidant enzymes by...

article

Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats

Sridhar Muthusami, Ilangovan Ramachandran, Balaganesh Muthusamy, Gopalakrishnan Vasudevan, more

Clinica Chimica Acta > 2005 > 360 > 1-2 > 81-86

There is increasing evidence suggesting the role of free radicals in bone resorption and bone loss. Ovariectomized rats have been used as the animal model for the study of osteoporosis. Oxidative stress due to reactive oxygen species (ROS) can cause oxidative damage to cells. Cells have a number of defense mechanisms to protect themselves from the toxicity of ROS. Even though, there are studies portraying...

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