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β-Secretase (β-SEC) is one of the prime targets for therapeutic intervention of Alzheimer’s disease. We previously described the expression of human β-SEC in Trichoplusia ni BTI Tn5B1-4 cells transformed with cDNAs encoding β1,4-galactosyltransferase (GalT) and Galβ1,4-GlcNAc α2,6-sialyltransferase (ST). To extend this work we investigated the kinetics of recombinant β-secretase and the feasibility...