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AbstractFocal cerebral ischemia in the rat has traditionally been studied by examining the consequences of middle-cerebral artery occlusion. However, the anterior-cerebral arteries of the rat may now also be bilaterally occluded by stereotaxic injection of the vasoconstrictor endothelin-1, resulting in ischemic damage to medial prefrontal cortex and the anteromedial basal forebrain. The behavioural...
Abstract This study examined the effects of systemic amphetamine in rats performing a reaction time task in which motivation and motor readiness were independently varied. Visual cues indicated the number of trials (one, two or three) needed before reinforcement was made available (i.e., reward cost). Lower reward cost was reflected in both a greater proportion of correctly completed trials and faster...
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